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New methods to induce skeletal muscle hypertrophy using reactive oxygen species

Research Project

Project/Area Number 26560375
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research Institution防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工学群) (2015-2016)
Ritsumeikan University (2014)

Principal Investigator

Makanae Yuhei  防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工, 総合教育学群, 助教 (00706632)

Co-Investigator(Renkei-kenkyūsha) Fujita Satoshi  立命館大学, スポーツ健康科学部, 教授 (80451863)
Nakazato Koichi  日本体育大学, 保健医療学部, 教授 (00307993)
Sato Koji  神戸大学, 人間発達環境学研究科, 准教授 (20584022)
Ogasawara Riki  名古屋工業大学, 工学系研究科, 准教授 (10634602)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords運動 / 骨格筋 / mTORC1 / 活性酸素種 / レジスタンス運動 / 骨格筋肥大
Outline of Final Research Achievements

The purpose of this study was to investigate the effects of reactive oxygen species (ROS) injection and the combination of ROS injection and resistance exercise on the mTORC1 activity. The exogenous increase in ROS stimulated mTORC1 activity at basal state. However, it did not further stimulate resistance exercise-induced mTORC1 activation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Presentation (4 results) (of which Int'l Joint Research: 2 results) Funded Workshop (1 results)

  • [Presentation] Hydrogen peroxide does not potentiate exercise-induced mTORC1 in rat skeletal muscle2016

    • Author(s)
      Y. Makanae, Y. Takamura, S. Ato, K. Kido, T. Miyake, S. Fujita
    • Organizer
      American College of Sports Medicine 63th Annual meeting,
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Resistance exercise-induced reactive oxygen species in rat skeletal muscle activates mTORC1 via Erk1/2 signaling.2015

    • Author(s)
      Yuhei Makanae, Riki Ogasawara, Koji Sato, Kenji Matsutani, Naruhiro Shiozawa, Koichi Nakazato, Satoshi Fujita.
    • Organizer
      American College of Sports Medicine 62nd Annual Meeting
    • Place of Presentation
      California, USA
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The vitamin D receptor and CYP27B1 increase after resistance exercise but not after endurance exercise.2014

    • Author(s)
      Yuhei Makanae
    • Organizer
      ACSM Conference on Integrative Physiology of Exercise
    • Place of Presentation
      Miami, Florida USA,
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Antioxidant inhibits phosphorylation of p70s6k after resistance exercise in rats2014

    • Author(s)
      Yuhei Makanae
    • Organizer
      American College of Sports Medicine, 61st Annual Meeting
    • Place of Presentation
      Orlando, Florida USA
    • Year and Date
      2014-05-30
    • Related Report
      2014 Research-status Report
  • [Funded Workshop] American College of Sports Medicine 63th Annual meeting2016

    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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