Is hibernation-specific protein mimetic human CTRP3 a biosensor for homeostatic balance?
| Project/Area Number |
26560389
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | CTRP3 / 生活習慣病 / バイオセンサー / NAFLD / 過体重 / 脂質異常 / 高血圧 / インスリン抵抗性 / 応用健康科学 / 代謝恒常性 / バイオマーカー / 脂肪肝 / 生体恒常性 |
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| Outline of Final Research Achievements |
The aim of the present study was to investigate the significance of serum C1q/TNF-related protein-3 (CTRP3) in the context of lifestyle-related diseases among non-obese young adults. We investigated 261 non-obese university freshmen (160 men and 101 women). Serum CTRP3 level was negatively correlated with BMI and systolic and diastolic blood pressures. It also negatively correlated with triglyceride, LDL-cholesterol, and HOMA-IR. In contrast, it positively correlated with HDL-cholesterol. CTRP3 level in non-alcoholic fatty liver disease (NAFLD) group was significantly higher than that in non-NAFLD group. Since serum CTRP3 level decreases in the presence of hypertension, dyslipidemia, overweight, and NAFLD, it is considered to be a biosensor to reflect the risk of lifestyle-related diseases.
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Report
(3 results)
Research Products
(10 results)
