Increase in fat oxidation during post-exercise period: endocrine & metabolic analysis

• Project/Area Number: 26560390
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: TOKUYAMA Kumpei 筑波大学, 体育系, 教授 (00207565)
• Co-Investigator(Kenkyū-buntansha): SATOH Makoto 筑波大学, 国際統合睡眠医科学研究機構, 教授 (50242409) ; OGATA Hitomi 筑波大学, 体育系, 特別研究員(RPD) (80455930)
• Co-Investigator(Renkei-kenkyūsha): NAGASAKA Shoichiro 自治医科大学, 医学部, 講師 (00296112)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: エネルギー代謝 / ヒューマン・カロリメータ / メタボリック・チャンバー / 朝練習 / 脂肪酸組成

Outline of Final Research Achievements

Metabolic and endocrine response to exercise depends on when the exercise is performed. Present study evaluated the effect of aerobic exercise performed before breakfast or after lunch on 24-h fat oxidation and profile of plasma FFA. Exercise performed before breakfast increased 24-h fat oxidation, plasma FFA, saturated fatty acid and unsaturated fatty acid, but that performed after lunch had little effect. Present study suggest that increased 24-h fat oxidation after exercise performed before breakfast is at least due to activation of PDK4 by FFA and PPARα by polyunsaturated fatty acid (ω-3 fatty acid).

Research Products

• [Journal Article] Transient energy deficit induced by exercise increases 24-h fat oxidation in young trained men (2015)
  • Author(s): Iwayama K, Kawabuchi R, Park I, Kurihara R, Kobayashi M, Hibi M, Oishi S, Yasunaga K, Ogata H, Nabekura Y, Tokuyama K.
  • Journal Title: J Appl Physiol Volume: 118 Issue: 1 Pages: 80-85
  • DOI: 10.1152/japplphysiol.00697.2014
  • Peer Reviewed / Open Access
• [Journal Article] Exercise increases 24-h fat oxidation only when it is performed before breakast (2015)
  • Author(s): Kaito Iwayama, Reiko Kurihara, Yoshiharu Nabekura, Ryosuke Kawabuchi, Insung Park, Masashi Kobayashi, Hitomi Ogata, Momoko Kayaba, Makoto Satoh, Kumpei Tokuyama
  • Journal Title: EBioMedicine Volume: 2 Issue: 12 Pages: 2003-2009
  • DOI: 10.1016/j.ebiom.2015.10.029
  • Peer Reviewed / Open Access
• [Journal Article] Transient energy deficit induced by exercise increases 24-h fat oxidation in young trained men. (2015)
  • Author(s): Iwayama K, Kawabuchi R, Park I, Kurihara R, Kobayashi M, Hibi M, Oishi S, Yasunaga K, Ogata H, Nabekura Y, Tokuyama K.
  • Journal Title: J Appl Physiol Volume: 118 Pages: 80-85
  • Peer Reviewed / Open Access
• [Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. (2014)
  • Author(s): Lan F, Misu H, Chikamoto K, Takayama H, Kikuchi A, Mohri K, Takata N, Hayashi H, Matsuzawa-Nagata N, Takeshita Y, Noda H, Matsumoto Y, Ota T, Nagano T, Nakagen M, Miyamoto K, Takatsuki K, Seo T, Iwayama K, Tokuyama K, Matsugo S, Tang H, Saito Y, Yamagoe S, Kaneko S, Takamura T.
  • Journal Title: Diabetes Volume: 63 Pages: 1649-1664
  • NAID: 120005440333
  • Peer Reviewed / Open Access
• [Journal Article] Effects of nutrient composition of dinner on sleep architecture and energy metabolism during sleep. (2014)
  • Author(s): Yajima K., T.Seya, K.Iwayama, M.Hibi, S.Hari, Y.Nakashima, H.Ogata, N.Omi, M.Satoh, K.Tokuyama.
  • Journal Title: J.Nutr.Sci.Vitaminol. Volume: 60 Pages: 114-121
  • NAID: 130004491364
  • Peer Reviewed / Open Access
• [Presentation] Doe breakfast matter endurance for athletes? (2016)
  • Author(s): Tokuyama K
  • Organizer: ENHS 2016
  • Place of Presentation: Kohn Kaen Convention Center, Kohn Kaen, Thiland
  • Year and Date: 2016-01-22
  • Int'l Joint Research / Invited
• [Presentation] Exercise acts as fat burning pills if it is taken before breakfast. (2015)
  • Author(s): Iwayama K., Y.Nabekura, R.Kurihara, R.Kawabuchi, I.Park, H.Ogata, A.Ogawa, A.Ando, M.Kayaba, K.Tokuyama.
  • Organizer: Cell Symposia “Exercise Metabolism”
  • Place of Presentation: NH Grand Hotel Krasnaplosky, Amsterdam, The Netherland
  • Year and Date: 2015-07-12
  • Int'l Joint Research