development of in vivo imaging system for skeletal muscle biology

Research Project

Project/Area Number	26560394
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Applied health science
Research Institution	The University of Tokyo
Principal Investigator	AKIMOTO Takayuki 東京大学, 医学(系)研究科(研究院), 講師 (00323460)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	in vivoイメージング / 筋 / シグナル伝達 / 動的環境 / メカニカルストレス / 動的状態
Outline of Final Research Achievements	We developed an in vivo imaging system to combine spining-disc conforcal system with sensitive CCD camera. As a result of this project, we observed that the Nuclear factor of activated T-cells（NFAT）were translocated into nucleus in response to muscle contraction in adult skeletal muscle. We will apply this technique to see various phenomena in skeletal muscle in near the future

Report

(3 results)