Involvement of glycolytic metabolite in pathogenic mechanism of diabetes: verification of new model of insulin-resistance development
| Project/Area Number |
26560397
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Kyoto University |
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Principal Investigator |
Nomura Wataru 京都大学, (連合)農学研究科(研究院), 助教 (60724292)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | メチルグリオキサール / インスリンシグナル / インスリン抵抗性 / IRS-1 / mTORC1 |
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| Outline of Final Research Achievements |
It is pointed out that the methylglyoxal, a metabolite derived from glycolysis, is involved in diabetes, although the correlation between pathogenic mechanism of diabetes and methylglyoxal is unclear. The phosphorylation at Ser/Thr residues of IRS-1 (insulin receptor substrate) is one of the causes of insulin resistance. In this study, I found that the phosphorylation of IRS-1 is enhanced following treatment with methylglyoxal in adipocytes, and the pretreatment with methylglyoxal attenuates the activation of insulin signaling pathway.
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Report
(3 results)
Research Products
(2 results)
