Clarification of afferent pathway in exercise-induced enahncement in central regulatory sysytem of energy metabolism
Project/Area Number |
26560398
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied health science
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Research Institution | The University of Tokushima |
Principal Investigator |
SHIUCHI Tetsuya 徳島大学, 大学院医歯薬学研究部, 准教授 (70372729)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 運動 / 視床下部 / レプチン / レプチン感受性 / オレキシン |
Outline of Final Research Achievements |
In this study, leptin sensitivity in hypothalamus after endurance exercise and its mechanism were examined. Male C57BL/6J mice were performed treadmill running for 45 minutes. After that, leptin was injected intraperitoneally. Forty-five minutes later, hypothalamus in mice was collected, and determined the phosphorylation of STAT3 by western blot or immunohistochemistry. Treadmill running enhanced STAT3 phosphorylation in hypothalamus of the mice by ip injection of leptin. Immunohistochemical staining revealed that treadmill running increased c-Fos expression in one neuropeptidergic neuron in hypothalamus of the mice. Intracelebroventricular injection of receptor antagonist of the neuropeptide inhibited the exercise-induced enhancement of STAT3 phosphorylation in hypothalamus by leptin. Taken together, it is suggested that the enhanced leptin sensitivity after exercise is mediated by activation of the neuropeptidergic neuron by exercise.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Intracerebroventricular injection of adiponectin regulates locomotor activity in rats2015
Author(s)
Miyatake Y, Shiuchi T, Ueta T, Taniguchi Y, Futami A, Sato F, Kitamura T, Tsutsumi R, Harada N, Nakaya Y, Sakaue H.
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Journal Title
The Journal of Medical Investigation
Volume: 62
Issue: 3.4
Pages: 199-203
DOI
NAID
ISSN
1343-1420, 1349-6867
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Intracerebroventricular injection of ghrelin decreases wheel running activity in rats2015
Author(s)
Yumiko Miyatake, Tetsuya Shiuchi, Tomoyo Ueta, Masashi Kuroda, Nagakatsu Harada, Hiroyoshi Sei, Yasuhiko Minokoshi, Koro Gotoh, Yutaka Nakaya, Hiroshi Sakaue
Organizer
Cell Symposia
Place of Presentation
Amsterdam, Nederland
Year and Date
2015-07-12
Related Report
Int'l Joint Research
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