| Project/Area Number |
26560408
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | National Defense Medical College |
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Principal Investigator |
HATTORI Hidemi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 助教 (80508549)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脂肪細胞 / 脂肪組織由来間質細胞 / グルコース / 線維芽細胞増殖因子 / エオタキシン / サイトカイン / アレルギー / ケモカイン |
|---|
| Outline of Final Research Achievements |
Excessive carbohydrate intake not only leads to store to adipose tissues as energy but also induces allergies. This study examined glucose- and fibroblast growth factor-2 (FGF-2)-induced cytokine and chemokine expression in adipocytes or adipose tissue-derived stromal cells in vitro to clarify the relationship between adipose tissue and allergies. Glucose and FGF-2 affected cytokine and chemokine secretion, including interleukin-6, monocyte chemotactic protein-1, keratinocyte-derived chemokine, and eotaxin. Allergies will be presumably induced by excess cytokine and chemokine secretion from adipose tissues when overweight children regularly eating high-carbohydrate diets suddenly switch to low-carbohydrate and protein diets.
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