The longitudinal relationship between the regional cerebral glucose metabolism and altered performance in gait function

• Project/Area Number: 26560409
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: FUJIWARA YOSHINORI 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50332367)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 脳糖代謝 / 歩行速度 / 縦断研究 / 高齢者 / 歩行機能 / 安静時脳糖代謝量 / FDG-PET

Outline of Final Research Achievements

This 5-year follow-up study was conducted to determine the longitudinal relationship between the baseline regional cerebral glucose metabolism using FDG-PET and altered performance in gait function in the following 5 years.
The present study has showed that lower metabolic activities in the cognitive area (posterior cingulate cortex) and visuomotor control areas (primary visual area, supplementary motor area, and putamen) of the brain are significant predictors of future impairment of gait speed.

Research Products

• [Journal Article] Engagement in paid work as a protective predictor of BADL disability in Japanese urban and rural community-dwelling elderly residents: An 8-year prospective study. (2015)
  • Author(s): Fujiwara Y, Shinkai S, Kobayashi E, Minami U, Suzuki H, Yoshida H, Ishizaki T, Kumagai S, Watanabe S, Furuna T Suzuki T.
  • Journal Title: Geriatr Gerontol Int. Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship between Alzheimer’s disease-like pattern of 18F-FDG and fasting plasma glucose levels in cognitively normal volunteers. (2015)
  • Author(s): Ishibashi1 K, Onishi A, Fujiwara Y, Ishiwata K, Ishii K.
  • Journal Title: The Journal of Nuclear Medicin. Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cognitive intervention through a training program for picture book reading in community-dwelling older adults: a randomized controlled trial. (2014)
  • Author(s): Suzuki H, Kuraoka M, Yasunaga M, Nonaka K, Sakurai R, Takeuchi R, Murayama Y, Ohba H, Fujiwara Y
  • Journal Title: BMC Geriatrics Volume: 21 Issue: 1 Pages: 14-14
  • DOI: 10.1186/1471-2318-14-122
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Influential factors affecting age-related self-overestimation of step-over ability: Focusing on frequency of going outdoors and executive function. (2014)
  • Author(s): Sakurai R, Fujiwara Y, Sakuma N, Suzuki H, Ishihara M, Higuchi T, Imanaka K
  • Journal Title: Arch Gerontol Geriatr. Volume: 59 Issue: 3 Pages: 577-83
  • DOI: 10.1016/j.archger.2014.07.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Regional cerebral glucose metabolism and gait speed in healthy community-dwelling older women. (2014)
  • Author(s): Sakurai R, Fujiwara Y, Yasunaga M, Takeuchi R, Murayama Y, Ohba H, Sakuma N, Suzuki H, Oda K, Sakata M, Toyohara J, Ishiwata K, Shinkai S, Ishii K
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 69 Issue: 12 Pages: 1519-27
  • DOI: 10.1093/gerona/glu093
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reference Values and Age and Sex Differences in Physical Performance Measures for Community-Dwelling Older Japanese: A Pooled Analysis of Six Cohort Studies (2014)
  • Author(s): Seino S, Shinkai S, Fujiwara Y, Obuchi S, Yoshida H, Hirano H, Kim HK, Ishizaki T, Takahashi R; TMIG-LISA Research Group
  • Journal Title: PLOS ONE Volume: 9 Issue: 6 Pages: e99487-e99487
  • DOI: 10.1371/journal.pone.0099487
  • Peer Reviewed / Open Access
• [Journal Article] The effect of intergenerational programs on the mental health of elderly adults. (2014)
  • Author(s): Murayama Y, Ohba H, Yasunaga M, Nonaka K, Takeuchi R, Nishi M, Sakuma N, Uchida H, Shinkai S, Fujiwara Y.
  • Journal Title: Aging Ment Health. Volume: 19(4) Issue: 4 Pages: 306-314
  • DOI: 10.1080/13607863.2014.933309
  • Peer Reviewed / Open Access
• [Journal Article] Nutritional biomarkers and subsequent cognitive decline among community-dwelling older Japanese: A prospective study. (2014)
  • Author(s): Taniguchi Y, Shinkai S, et al （他5名）
  • Journal Title: Journal of Gerontology: Biological Sciences & Medical Sciences Volume: 印刷中 Issue: 10 Pages: 1276-1283
  • DOI: 10.1093/gerona/glt286
  • Peer Reviewed / Open Access
• [Presentation] One-year change in Montreal Cognitive Assessment performance and related predictors in community-dwelling older adults. (2014)
  • Author(s): Fujiwara Y, Suzuki H, Kawai H, Hirano H, Yoshida H, Ihara K, Chaves P.H.M Obuchi S.
  • Organizer: Gerontological Society of America's 67th Annual Scientific Meeting.
  • Place of Presentation: Washington D.C.
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] Gait speed, executive function, and cerebral glucose metabolism in older adults. (2014)
  • Author(s): Sakurai R, Fujiwara Y, Yasunaga M, Murayama Y, Sakuma N, Kobayashi K, Shinkai S Ishii K
  • Organizer: Gerontological Society of America's 67th Annual Scientific Meeting.
  • Place of Presentation: Washington D.C.
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] Cognitive characteristics of community-dwelling older people with mild cognitive impairment as assessed by the Japanese version of the Montreal cognitive assessment. (2014)
  • Author(s): Suzuki H, Fujiwara Y, Kawai H, Hirano H, Yoshida H, Ihara K Obuchi S.
  • Organizer: Gerontological Society of America's 67th Annual Scientific Meeting.
  • Place of Presentation: Washington D.C.
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] Effect of Intergenerational Programs between Primary School children and Senior Volunteers on the self-efficacy of children. (2014)
  • Author(s): Yasunaga M, Murayama Y, Takeuchi R, Ohba H, Nonaka K, Nishi M, Fujiwara Y Shinkai S.
  • Organizer: Gerontological Society of America's 67th Annual Scientific Meeting.
  • Place of Presentation: Washington,D.C
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] ソーシャルキャピタルの概念に基づく住民活動の類型化とその評価. (2014)
  • Author(s): 藤原佳典.
  • Organizer: 第73回日本公衆衛生学会総会.
  • Place of Presentation: 宇都宮
  • Year and Date: 2014-11-05 – 2014-11-07
  • Invited
• [Presentation] 手指巧緻性と認知機能の関連に関与する安静時脳糖代謝変化. (2014)
  • Author(s): 桜井良太, 藤原佳典, 安永正史, 村山陽, 大場宏美, 鈴木宏幸, 新開省二, 石井賢二
  • Organizer: 第56回日本老年医学会学術集会.
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-12 – 2014-06-14
• [Presentation] 認知機能低下が高齢者のソーシャルキャピタル劣化に及ぼす影響. (2014)
  • Author(s): 藤原佳典，鈴木宏幸，河合恒，深谷太郎，安永正史，平野浩彦，吉田英世，小島基永，井原一成，大渕修一.
  • Organizer: 第56回日本老年医学会総会.
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-12 – 2014-06-14
• [Presentation] 見守りセンサーを用いた独居高齢者の生活支援策の開発（その１）－利用者のアウトカム評価－ －首都圏高齢者の地域包括的孤立予防研究(CAPITAL study)より－. (2014)
  • Author(s): 藤原佳典,長谷部雅美,野中久美子,小池高史,深谷太郎,村山幸子,李ギョン娥,植木章三,吉田裕人,亀井智子,渡辺修一郎
  • Organizer: 日本老年社会科学会第56回大会
  • Place of Presentation: 岐阜
  • Year and Date: 2014-06-07 – 2014-06-08
• [Presentation] The effect of intergenerational program in an elementary school on the attitude toward community activities in their junior high school days. (2014)
  • Author(s): Murayama Y, Yasunaga M, Takeuchi R, Ohba H, Nonaka K Fujiwara Y.
  • Organizer: 6th Annual Meeting, International Society for Social Capital research.
  • Place of Presentation: Auckland NZ
  • Year and Date: 2014-06-01 – 2014-06-05
• [Book] 社会福祉士養成講座⑬ (2015)
  • Author(s): 藤原佳典 (川廷宗之、高橋信幸、和気純子編集)
  • Total Pages: 300
  • Publisher: 中央法規出版株式会社
• [Book] 基礎からわかる軽度認知障害（MCI） (2015)
  • Author(s): 藤原佳典 (鈴木隆雄監修、島田裕之編集)
  • Total Pages: 344
  • Publisher: 株式会社医学書院
• [Book] 完全版介護予防マニュアル (2015)
  • Author(s): 藤原佳典 (鈴木隆雄、島田裕之、大渕修一監修 )
  • Total Pages: 499
  • Publisher: 株式会社法研
• [Book] 『地域を変えた「絵本の読み聞かせ」のキセキ―シニアボランティアはソーシャルキャピタルの源泉 現役シニアボランティアが選ぶ子どもたちに何度でも読んであげたい絵本 ぞくぞく101選』 (2015)
  • Author(s): 藤原佳典
  • Total Pages: 200
  • Publisher: 株式会社ライフ出版
• [Book] 公衆衛生実践キーワード－地域保健活動の今がわかる明日が見える－ (2014)
  • Author(s): 藤原佳典 (鳩野洋子、島田美喜編集)
  • Total Pages: 208
  • Publisher: 株式会社医学書院