Hybrid protein needle for controlling model animal functions
| Project/Area Number |
26560433
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biomolecular chemistry
|
|---|
| Research Institution | Tokyo Institute of Technology |
|---|
Principal Investigator |
UENO Takafumi 東京工業大学, 生命理工学研究科, 教授 (70332179)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takashi 東京工業大学, 大学院生命理工学研究科, 准教授 (60612760)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | タンパク質工学 / ケミカルバイオロジー / 一酸化炭素 / フェリチン / バクテリオファージ T４ / タンパク質 / 生体材料 / ナノバイオ / バイオテクノロジー / 分子機械 / 蛋白質 |
|---|
| Outline of Final Research Achievements |
This research shows that (1) protein assemblies have advantages as CO releasing molecules, (2) protein needle with optimized surface charge can accumulate on brain of larva. The future challenges, which should be addressed, are (1) ROS and NO assay of eye disc, (2) the ROS imaging, (3) assay for expression of HO and NOS, and (4) inhibitory assay of sGC activation by CO.
|
Report
(3 results)
Research Products
(8 results)
