Design of smart drugs that are activated upon X-irradiation
| Project/Area Number |
26560446
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Aoyama Gakuin University (2015)
Kyoto University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Ｘ線照射 / ドラッグキャリア / ＤＮＡ会合体 / 放射線 / X線照射 / ジスルフィド結合 |
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| Outline of Final Research Achievements |
We have designed a novel aggregate of DNA amphiphiles (DAM) that is sensitive to X-irradiation or photoirradiation. The DAM consists of alkyl chain as a hydrophobic unit and oligodeoxynucleotides as a hydrophilic unit, which are linked to a radiation-sensitive azobenzen derivative (DAM-Azo). The DAM-Azo self-assembled efficiently to form aggregates that encapsulated small molecules such as pyrene. X-irradiation could then induce reductive degradation of the DAM-Azo aggregates via degradation of the azobenzene unit to release guest molecules. We also prepared photo-responsive aggregate using photoreactive nitrobenzene unit. The nitrobenzene unit was introduced into oligonucleotide (P-ODN), whose reaction was characterized. P-ODN showed a proper function as photosensitive drug carrier.
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Report
(3 results)
Research Products
(9 results)
