| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
We have designed a novel aggregate of DNA amphiphiles (DAM) that is sensitive to X-irradiation or photoirradiation. The DAM consists of alkyl chain as a hydrophobic unit and oligodeoxynucleotides as a hydrophilic unit, which are linked to a radiation-sensitive azobenzen derivative (DAM-Azo). The DAM-Azo self-assembled efficiently to form aggregates that encapsulated small molecules such as pyrene. X-irradiation could then induce reductive degradation of the DAM-Azo aggregates via degradation of the azobenzene unit to release guest molecules. We also prepared photo-responsive aggregate using photoreactive nitrobenzene unit. The nitrobenzene unit was introduced into oligonucleotide (P-ODN), whose reaction was characterized. P-ODN showed a proper function as photosensitive drug carrier.
|
