Functional evaluation in animal models of radiosurgical brain lesions
| Project/Area Number |
26560454
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Tanaka Masaki 北海道大学, 医学研究院, 教授 (90301887)
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| Co-Investigator(Renkei-kenkyūsha) |
KUNIMATU JUN 北海道大学, 大学院医学研究科, 助教 (50632395)
TAKEYA RYUJI 北海道大学, 大学院医学研究科, 助教 (00756322)
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| Research Collaborator |
ISHIKAWA MASAYORI 北海道大学, 大学院医学研究科, 教授 (80314772)
MIYAMOTO NAOKI 北海道大学, 大学院医学研究科, 助教 (00552879)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 霊長類 / 事象関連電位 / X線照射 / 脳疾患モデル / 眼球運動 / 行動評価 / 化学遺伝学 / 小脳 / 深部照射 / 機能脱落 / 定位照射 / 深部脳破壊 / 脳機能評価 / 動物モデル / 放射線定位照射 / 脳機能 / リニアック |
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| Outline of Final Research Achievements |
Experimental technique to produce focal brain lesions may provide opportunities for future research exploring mechanisms of brain function and recovery from injury. As a candidate method, we evaluated the radiosurgical technique. We also tried to develop behavioral and electrophysiological techniques to examine subcortical brain functions, and explored new methods to generate focal brain lesions. We evaluated the oculomotor behavior in monkeys up to 8 months following irradiation to the frontal eye field. In addition, we have developed several behavioral tasks and a method to record cortical potentials through epi-dural electrodes, both of which are usable to detect subcortical dysfunction. Further, we performed a feasible study of chemogenetic application to monkeys by injecting a viral vector into the cerebellum. Through these studies, we could obtain valuable information for future studies.
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Report
(4 results)
Research Products
(59 results)
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[Presentation] Subcortical mechanism of self-timing.2017
Author(s)
Tanaka, M.
Organizer
The 12th International Basal Ganglia Society Meeting (IBAGS2017) Session 3: Neurophysiology and behavior in non-human primates
Place of Presentation
Fiesta Americana Merida（Merida, Mexico）
Year and Date
2017-03-26
Related Report
Int'l Joint Research / Invited
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[Presentation] 眼球運動と高次機能2015
Author(s)
田中真樹
Organizer
生理学研究所研究会
Place of Presentation
生理学研究所(愛知県岡崎市)
Year and Date
2015-12-04
Related Report
Invited
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[Presentation] 小脳の時間情報2015
Author(s)
田中真樹
Organizer
東京都医学研究所セミナー
Place of Presentation
東京都医学総合研究所(東京都世田谷区)
Year and Date
2015-05-29
Related Report
Invited
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[Presentation] 大脳小脳連関と高次機能2015
Author(s)
田中真樹
Organizer
平成26年度 京大霊長研共同利用研究会
Place of Presentation
京都大学霊長類研究所（犬山市）
Year and Date
2015-03-13
Related Report
Invited
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[Presentation] 計時と予測の神経機構2014
Author(s)
田中真樹
Organizer
日本神経回路学会オータムスクール（ASCONE）
Place of Presentation
かたくら諏訪湖ホテル（諏訪市）
Year and Date
2014-11-02
Related Report
Invited
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