| Project/Area Number |
26560455
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
林 拓也 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (50372115)
尾上 浩隆 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (80214196)
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| Research Collaborator |
NAKAMURA Shinya
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳・神経 / 抑うつ / サルうつ病モデル / 経頭蓋磁気刺激 |
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| Outline of Final Research Achievements |
We applied low-frequency repetitive trans-cranial magnetic stimulation (lf-rTMS) to the ventral part of the medial prefrontal cortex (vmPFC) in rhesus monkeys. After the stimulation, all these monkeys fell into a severe depressive state, which lasted for 1 - 3 days. Such state could be characterized by reduction of within-cage spontaneous activity, reduction of motivation to perform behavioral tasks, and increase in the blood cortisol level. On the other hand, similar stimulation on the posterior part of the anterior cingulate cortex (pACC), or any other cortical regions, did not induce such drastic change in mood. We performed functional MR imaging (fMRI) to measure the resting-state whole brain activity after lf-rTMS to vmPFC and pACC, and sham stimulation to vmPFC. The data is now being analyzed to reveal the difference of the brain activity between the depressive and normal state.
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