Epigenetics of developmental abnormality of biological rhythms

• Project/Area Number: 26560460
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Basic / Social brain science
• Research Institution: Kyoto University
• Principal Investigator: OKAMURA Hitoshi 京都大学, 薬学研究科(研究院), 教授 (60158813)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 生物リズム・エピジェネティックス / 生体リズム / エピジェネティックス

Outline of Final Research Achievements

Many psychiatric disorders such as manic depression and schizophrenia, are speculated to be caused by genetic predisposition and environmental factors. Circadian rhythm is also known as a brain function, and its molecular mechanisms are now well clarified. Here we examined the effect of haploinsufficiency of clock oscillatory system. Genetically uniform vulnerable mouse was nursed by normal mice or by mice with dysregulated clock at the time of breeding. Epigenetic effect was examined by measuring the period length of circadian behaviors. The results suggests that genetically determined circadian characteristics can be altered by epigenetic factors.

Research Products

• [Journal Article] 生体リズムの周期はメッセンジャーRNAのメチル化で変動する (2014)
  • Author(s): Fustin Jean-Michel, 岡村均
  • Journal Title: 医学のあゆみ Volume: 251 Pages: 179-180
• [Journal Article] Ecto-domain phosphorylation promotes neurogenesis and regeneration of the central nervous system from traumatic injury (2014)
  • Author(s): Kenji Suehiro, Yuka Nakamura, Shuai Xu, Yohichi Uda, Takafumi Matsumura, Yoshiaki Yamaguchi, Hitoshi Okamura, Toshihide Yamashita and Yoshinori Takei
  • Journal Title: Sci. Rep Volume: Vol.4 Issue: 1 Pages: 4972-4972
  • DOI: 10.1038/srep04972
  • Peer Reviewed / Open Access
• [Journal Article] Steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions (2014)
  • Author(s): Azmahani A, Nakamura Y, Felizola SJ, Ozawa Y, Ise K, Inoue T, McNamara KM, Doi M, Okamura H, Zouboulis CC, Aiba S, and Sasano H
  • Journal Title: J. Steroid Biochem. Mol. Biol. Volume: 144 Pages: 268-279
  • DOI: 10.1016/j.jsbmb.2014.07.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Angiotensin II Triggers Expression of the Adrenal Gland Zona Glomerulosa-Specific 3β-Hydroxysteroid Dehydrogenase Isoenzyme through de novo Protein Synthesis of the Orphan Nuclear Receptors NGFIB and NURR1. (2014)
  • Author(s): Takumi Ota, Masao Doi, Fumiyoshi Yamazaki, Daisuke Yarimizu, Kazuki Okada, Iori Murai, Hida Hayashi, Sumihiro Kunisue, Yuuki Nakagawa, Hitoshi Okamura
  • Journal Title: Molecular and Cellular Biology Volume: 34 Issue: 20 Pages: 3880-3894
  • DOI: 10.1128/mcb.00852-14
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 地球と時間と時計遺伝子 (2014)
  • Author(s): 岡村均
  • Organizer: 第39回日本睡眠学会定期学術集会
  • Place of Presentation: あわぎんホール（徳島）
  • Year and Date: 2014-07-03 – 2014-07-04
  • Invited
• [Presentation] New inter- and intracellular regulations of the circadian pacemaker (2014)
  • Author(s): Okamura Hitoshi
  • Organizer: 14th SRBR Meeting
  • Place of Presentation: Big Sky, Montana (USA)
  • Year and Date: 2014-06-15 – 2014-06-18
  • Invited
• [Presentation] クロノメタボリズム：時間相の医学生物学 (2014)
  • Author(s): 岡村均
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2014-04-11 – 2014-04-12
  • Invited
• [Book] 脳内環境―維持機構と破綻がもたらす疾患研究（遺伝子医学MOOK26）（ (2014)
  • Author(s): 漆谷 真, 山中宏二, 樋口真人 高橋良輔 (編集)
  • Total Pages: 228
  • Publisher: メディカルﾄﾞｳ