| Project/Area Number |
26560465
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Brain biometrics
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| Research Institution | Kyoto University |
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Principal Investigator |
Matsumoto Riki 京都大学, 医学(系)研究科(研究院), 准教授 (00378754)
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| Co-Investigator(Kenkyū-buntansha) |
KUNIEDA Takeharu 京都大学, 大学院医学研究科, 講師 (60609931)
SHIMOTAKE Akihiro 京都大学, 大学院医学研究科, 助教 (80726000)
INOUCHI Morito 京都大学, 大学院医学研究科, 助教 (30532600)
KOBAYASHI Katsuya 京都大学, 大学院医学研究科, 助教 (70737121)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Akio 京都大学, 大学院医学研究科, 教授 (90212761)
OKADA Tomohisa 京都大学, 大学院医学研究科, 准教授 (30321607)
MATSUHASHI Masao 京都大学, 大学院医学研究科, 准教授 (40456885)
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| Research Collaborator |
USAMI Kiyohide Johns Hopkins University, Department of Neurology, Visiting scientist
YAMAO Yukihiro 前King's College London, Visiting Researcher
NAKAE Takuro 京都大学, 大学院医学研究科, 大学院生
TOGO Masaya 京都大学, 大学院医学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 機能的結合 / 脳機能計測 / 皮質皮質間誘発電位 / 安静時機能MRI / 高周波律動 / てんかん / 睡眠 / 皮質間ネットワーク / 皮質間結合 / 皮質電気刺激 |
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| Outline of Final Research Achievements |
Recent development in biological signal analysis has enabled us to explore much wider range of neural oscillation in living human brains, ranging from very low frequency oscillation (<0.1 Hz) of BOLD signal to high frequency activities (>100 Hz) recorded in electrocorticogram. In this study, we recruited patients with epilepsy and tumor who underwent invasive presurgical evaluation with intracranial electrodes. We first non-invasively obtained resting state fMRI data before surgery. We then, during electrode implantation, applied single-pulse electrical stimulation to a part of the cortices to record cortico-cortical evoked potentials or induced neural oscillations through cortico-cortical connections. We focused on the physiological (sleep) and pathologic (epilepsy) states and revealed their network dynamics. We also launched comprehensive investigation to establish the human brain connectivity map, focusing on the higher brain functions relevant to clinical system neuroscience.
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