Mapping human brain connectivity by analyzing spontaneous and stimulation-induced neural oscillations

• Project/Area Number: 26560465
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Brain biometrics
• Research Institution: Kyoto University
• Principal Investigator: Matsumoto Riki 京都大学, 医学(系)研究科(研究院), 准教授 (00378754)
• Co-Investigator(Kenkyū-buntansha): KUNIEDA Takeharu 京都大学, 大学院医学研究科, 講師 (60609931) ; SHIMOTAKE Akihiro 京都大学, 大学院医学研究科, 助教 (80726000) ; INOUCHI Morito 京都大学, 大学院医学研究科, 助教 (30532600) ; KOBAYASHI Katsuya 京都大学, 大学院医学研究科, 助教 (70737121)
• Co-Investigator(Renkei-kenkyūsha): IKEDA Akio 京都大学, 大学院医学研究科, 教授 (90212761) ; OKADA Tomohisa 京都大学, 大学院医学研究科, 准教授 (30321607) ; MATSUHASHI Masao 京都大学, 大学院医学研究科, 准教授 (40456885)
• Research Collaborator: USAMI Kiyohide Johns Hopkins University, Department of Neurology, Visiting scientist ; YAMAO Yukihiro 前King's College London, Visiting Researcher ; NAKAE Takuro 京都大学, 大学院医学研究科, 大学院生 ; TOGO Masaya 京都大学, 大学院医学研究科, 大学院生
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 機能的結合 / 脳機能計測 / 皮質皮質間誘発電位 / 安静時機能MRI / 高周波律動 / てんかん / 睡眠 / 皮質間ネットワーク / 皮質間結合 / 皮質電気刺激

Outline of Final Research Achievements

Recent development in biological signal analysis has enabled us to explore much wider range of neural oscillation in living human brains, ranging from very low frequency oscillation (<0.1 Hz) of BOLD signal to high frequency activities (>100 Hz) recorded in electrocorticogram. In this study, we recruited patients with epilepsy and tumor who underwent invasive presurgical evaluation with intracranial electrodes. We first non-invasively obtained resting state fMRI data before surgery. We then, during electrode implantation, applied single-pulse electrical stimulation to a part of the cortices to record cortico-cortical evoked potentials or induced neural oscillations through cortico-cortical connections. We focused on the physiological (sleep) and pathologic (epilepsy) states and revealed their network dynamics. We also launched comprehensive investigation to establish the human brain connectivity map, focusing on the higher brain functions relevant to clinical system neuroscience.

Research Products

• [Int'l Joint Research] マンチェスター大学（University of Manchester）(英国)
• [Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy (2016)
  • Author(s): Imamura, H., R. Matsumoto, S. Takaya, T. Nakagawa, A. Shimotake, T. Kikuchi, N. Sawamoto, T. Kunieda, N. Mikuni, S. Miyamoto, H. Fukuyama, R. Takahashi and A. Ikeda
  • Journal Title: Epi Res Volume: 120 Pages: 65-72
  • DOI: 10.1016/j.eplepsyres.2015.12.003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The 'when' and 'where' of semantic coding in the anterior temporal lobe: Temporal representational similarity analysis of electrocorticogram data. (2016)
  • Author(s): Chen Y, Shimotake A, Matsumoto R, Kunieda T, Kikuchi T, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A, Lambon-Ralph MA
  • Journal Title: Cortex Volume: 印刷中 Pages: 1-13
  • DOI: 10.1016/j.cortex.2016.02.015
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reply to Commentary on "Neural correlates of mirth and laughter: a direct electrical cortical stimulation study" (2016)
  • Author(s): Yamao, Y., T. Kunieda, and R. Matsumoto
  • Journal Title: Cortex Volume: 75 Pages: 244-246
  • DOI: 10.1016/j.cortex.2015.03.019
  • Peer Reviewed / Open Access
• [Journal Article] Benign adult familial myoclonus epilepsy is a progressive disorder: no longer idiopathic generalized epilepsy (2016)
  • Author(s): Hitomi T, Kobayashi K, Sakurai T, Ueda S, Jingami N, Kanazawa K, Matsumoto R, Takahashi R, Ikeda A.
  • Journal Title: Epileptic Disord Volume: 18 Pages: 67-72
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] てんかん外科における術前皮質・白質機能マッピング（特集：神経生理最前線） (2016)
  • Author(s): 松本理器、下竹昭寛、山尾幸広、國枝武治
  • Journal Title: 最新精神医学 Volume: 21 Pages: 101-109
• [Journal Article] てんかん病態下の脳内ネットワーク (2016)
  • Author(s): 十川純平、松本理器、池田昭夫
  • Journal Title: Clinical Neuroscience Volume: 34
• [Journal Article] 皮質電気刺激によるヒト脳機能ネットワークの探索 (2016)
  • Author(s): 山尾幸広、國枝武治、松本理器
  • Journal Title: 脳神経外科速報 Volume: 25 Pages: 411-420
• [Journal Article] くすぶり型辺縁系脳炎と自律神経 (2016)
  • Author(s): 武山博文、松本理器、池田昭夫
  • Journal Title: 神経内科 Volume: 84 Pages: 58-61
• [Journal Article] Different Mode of Afferents Determines the Frequency Range of High Frequency Activities in the Human Brain: Direct Electrocorticographic Comparison between Peripheral Nerve and Direct Cortical Stimulation. (2015)
  • Author(s): Kobayashi K, Matsumoto R, Matsuhashi M, Usami K, Shimotake A, Kunieda T, Kikuchi T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: PLoS One. Volume: 10 (6)
  • DOI: 10.1371/journal.pone.0130461
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation (2015)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Shimotake A, Kikuchi T, Matsuhashi M, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A.
  • Journal Title: Hum Brain Mapp. Volume: 36(11) Pages: 0-0
  • DOI: 10.1002/hbm.22948
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Direct Exploration of the Role of the Ventral Anterior Temporal Lobe in Semantic Memory: Cortical Stimulation and Local Field Potential Evidence From Subdural Grid Electrodes. (2015)
  • Author(s): Shimotake A, Matsumoto R, Ueno T, Kunieda T, Saito S, Hoffman P, Kikuchi T, Fukuyama H, Miyamoto S, Takahashi R, Ikeda A, Lambon Ralph MA
  • Journal Title: Cereb Cortex Volume: 印刷中 Pages: 3802-17
  • DOI: 10.1093/cercor/bhu262
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural correlates of mirth and laughter: a direct electrical cortical stimulation study (2015)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Shibata S, Shimotake A, Kikuchi T, Satow T, Mikuni N, Fukuyama H, Ikeda A, Miyamoto S.
  • Journal Title: Cortex Volume: 66 Pages: 134-140
  • DOI: 10.1016/j.cortex.2014.11.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proceedings of the Seventh International Workshop on Advances in Electrocorticography (2015)
  • Author(s): Ritaccio A, Matsumoto R, Morrell M, Kamada K, Koubeissi M, Poeppel D, Lachaux JP, Yanagisawa Y, Hirata M, Guger C, Schalk G
  • Journal Title: Epilepsy and Behavior Volume: 51 Pages: 312-320
  • DOI: 10.1016/j.yebeh.2015.08.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential (2015)
  • Author(s): Kunieda T, Yamao Y, Kikuchi T, Matsumoto R
  • Journal Title: Neurologia medico-chirurgica Volume: 55(5) Issue: 5 Pages: 0-0
  • DOI: 10.2176/nmc.ra.2014-0388
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Network hyperexcitability in a patient with partial reading epilepsy: converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic resonance imaging. (2015)
  • Author(s): Fumuro T, Matsumoto R, Shimotake A, Matsuhashi M, Inouchi M, Urayama S, Sawamoto N, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Clincal Neurophysiology Volume: 126 (4) Pages: 675-681
  • DOI: 10.1016/j.clinph.2014.07.033
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A possible variant of negative motor seizure arising from the supplementary negative motor area (2015)
  • Author(s): Yamao Y, Matsumoto R, Kunieda K, Arakawa Y, Kikuchi T, Shibata S, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Clinical Neurology and Neurosurgery Volume: 134 Pages: 126-129
  • DOI: 10.1016/j.clineuro.2015.04.024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody. (2015)
  • Author(s): Matsumoto R, Mikuni N, Tanaka K, Usami K, Fukao K, Kunieda T, Takahashi Y, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A.
  • Journal Title: Epileptic Disord. Volume: 17(1) Pages: 89094-89094
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Alpha-band desynchronization in human parietal area during reach planning. (2015)
  • Author(s): Fumuro T, Matsuhashi M, Miyazaki T, Inouchi M, Hitomi T, Matsumoto R, Takahashi R, Fukuyama H, Ikeda A
  • Journal Title: Clin Neurophysiol. Volume: 126(4) Pages: 756-62
  • DOI: 10.1016/j.clinph.2014.07.026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] システム神経科学とてんかんの接点 (2015)
  • Author(s): 松本理器、國枝武治、池田昭夫
  • Journal Title: 最新医学 Volume: 70 Pages: 1051-1060
• [Journal Article] EMUの整備と課題 (2015)
  • Author(s): 池田昭夫、松本理器、國枝武治
  • Journal Title: Epilepsy Volume: 9 Pages: 23-28
• [Journal Article] 思春期・成人発症てんかんの治療 (特集 てんかん : 基礎・臨床研究の最新知見) (2015)
  • Author(s): 井上岳司、松本理器、池田昭夫
  • Journal Title: 日本臨床 Volume: 72 Pages: 853-858
• [Journal Article] Risk Factors for Infective Complications with Long-Term Subdural Electrode Implantation in Patients with Medically Intractable Partial Epilepsy. (2015)
  • Author(s): Shibata, S., T. Kunieda, R. Inano, M. Sawada, Y. Yamao, T. Kikuchi, R. Matsumoto, A. Ikeda, R. Takahashi, N. Mikuni, J. Takahashi and S. Miyamoto
  • Journal Title: World Neurosurg. Volume: - Pages: 320-326
  • DOI: 10.1016/j.wneu.2015.03.048
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] New Approach for Exploring Cerebral Functional Connectivity: Review of CCEP (Cortico-cortical evoked potential) (2015)
  • Author(s): Kunieda T, Yamao Y, Kikuchi T, Matsumoto R
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody. (2015)
  • Author(s): Matsumoto R, Mikuni N, Tanaka K, Usami K, Fukao K, Kunieda T, Takahashi Y, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Epileptic Disorder Volume: 17 (1) Pages: 89-94
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of CYP2C19 polymorphisms on the clinical outcome of low-dose clobazam therapy in Japanese patients with epilepsy. (2015)
  • Author(s): Hashi S, Yano I, Shibata M, Masuda S, Kinoshita M, Matsumoto R, Ikeda A, Takahashi R, Matsubara K.
  • Journal Title: European Journal of Clinical Pharmacology Volume: 71 Pages: 51-58
  • DOI: 10.1007/s00228-014-1773-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intracranially-recorded ictal direct current shifts may precede high frequency oscillations in human epilepsy (2015)
  • Author(s): Kanazawa K, Matsumoto R, Imamura H, Matsuhashi M, Kikuchi T, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
  • Journal Title: Clin Neurophysiol Volume: 126 Pages: 47-59
  • DOI: 10.1016/j.clinph.2014.05.028
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant. (2014)
  • Author(s): Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
  • Journal Title: Acta Neuropathologica Comm Volume: 2 Pages: 172-172
  • DOI: 10.1186/s40478-014-0172-0
  • Peer Reviewed / Open Access
• [Journal Article] Persistent frequent subclinical seizures and memory impairment after clinical remission in smoldering limbic encephalitis (2014)
  • Author(s): Kanazawa K, Matsumoto R, Shimotake A, Kinoshita M, Otsuka A, Watanabe O, Tanaka K, Takahashi R, Ikeda A
  • Journal Title: Epileptic Disorders Volume: 16(3) Pages: 312-317
  • Peer Reviewed
• [Journal Article] Long-term follow-up of cortical hyperexcitability in Japanese Unverricht-Lundborg disease (2014)
  • Author(s): Kobayashi K, Hitomi T, Matsumoto R, Kondo T, Kawamata J, Matsuhashi M, Hashimoto S, Ikeda H, Koide Y, Inoue Y, Takahashi R, Ikeda A.
  • Journal Title: Seizure Volume: 23 Pages: 746-750
  • DOI: 10.1016/j.seizure.2014.06.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. (2014)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, IkedaA, Fukuyama H, Miyamoto S
  • Journal Title: Human Brain Map Volume: (in press)(E-pub) Pages: 4345-4361
  • DOI: 10.1002/hbm.22479
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 急性無菌性髄膜脳炎の経過中に局所性皮質反射性ミオクローヌスを 呈し抗グルタミン酸受容体抗体が検出された 2 例 (2014)
  • Author(s): 戸島麻耶，人見 健文，陣上直人，谷岡洸介，山門穂高，松本理器，高橋幸利，池田昭夫，髙橋良輔
  • Journal Title: 臨床神経 Volume: 54 Pages: 543-549
  • Peer Reviewed / Open Access
• [Journal Article] 脳のゆらぎ・同期・オシレーション C. ヒトでの計測 6. 皮質脳波 (2014)
  • Author(s): 小林勝哉、松本理器
  • Journal Title: Clinical Neuroscience Volume: 32 Pages: 792-796
• [Journal Article] 側頭葉てんかんの認知機能と扁桃体 (2014)
  • Author(s): 武山博文、松本理器、三枝隆博、池田昭夫
  • Journal Title: Clinical Neuroscience Volume: 32 Pages: 680-682
• [Journal Article] 家族性側頭葉てんかん (2014)
  • Author(s): 麓直浩、松本理器、池田昭夫
  • Journal Title: 日本臨床 神経症候群（第2版）VI Volume: 別冊 Pages: 413-416
• [Presentation] Intracranially recorded ictal DC shifts and HFOs as surrogate markers of epileptogenicity in human focal epilepsy. (2016)
  • Author(s): Daifu M, Inouchi M, Kanazawa K, Matsuhashi M, Inoue T, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 2nd International workshop on High Frequency Oscillations in Epilepsy
  • Place of Presentation: Freiburg, Germany
  • Year and Date: 2016-03-10
  • Int'l Joint Research
• [Presentation] The ventral language network - its function, connectivity and plasticity: insights from direct cortical stimulation and ECoG recordings. (2015)
  • Author(s): Matsumoto R.
  • Organizer: Special Seminar at Cognitive Neurophysiology and Brain&#8211;Machine Interface Laboratory
  • Place of Presentation: Department of Neurology, Johns Hopkins Hospital, Baltimore, USA
  • Year and Date: 2015-12-08
  • Int'l Joint Research / Invited
• [Presentation] 皮質・皮質間誘発電位（ＣＣＥＰ）記録・解析の実際 (2015)
  • Author(s): 松本理器、國枝武治、池田昭夫
  • Organizer: 第45回日本臨床神経生理学会学術大会ワークショップ４．皮質・皮質間誘発電位
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] ヒト内側頭頂葉の機能的結合性：皮質―皮質間誘発電位を用いた検討 (2015)
  • Author(s): 十河正弥、松本理器、武山博文、小林勝哉、下竹昭寛、宇佐美清英、中江卓郎、國枝武治、宮本享、高橋良輔、池田昭夫
  • Organizer: 第45回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2015-11-05
• [Presentation] 慢性電極留置におけるてんかん原性評価 (2015)
  • Author(s): 小林勝哉、松本理器、國枝武治、池田昭夫
  • Organizer: 第45回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] 術中電気的線維追跡法を用いた腹側言語経路の検討 (2015)
  • Author(s): 中江卓郎、松本理器、國枝武治、荒川芳輝、下竹昭寛、小林勝哉、稲野理賀、西田誠、高橋由紀、稲田拓、菊池隆幸、松橋眞生、高橋良輔、池田昭夫、宮本享
  • Organizer: 第45回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2015-11-05
• [Presentation] Functional connectivity of the human entorhinal cortex: a cortico-cortical evoked potential study. (2015)
  • Author(s): Takeyama H, Matsumoto R, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
• [Presentation] 睡眠と前頭葉てんかん (2015)
  • Author(s): 小林勝哉、松本理器、宇佐美清英、國枝武治、池田昭夫
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
  • Invited
• [Presentation] 側頭葉底部前方領域での意味認知機能 マッピング：事象関連電位の皮質記録の検討 (2015)
  • Author(s): 下竹昭寛、松本理器、太田真紀子、國枝武治、三國信啓、宮本亨、高橋良輔、池田昭夫
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
• [Presentation] 高齢者のてんかん重積状態における頭部MRI拡散強調画像：臨床・脳波所見との相関 (2015)
  • Author(s): 吉村 元、松本 理器、上田 浩之、藤原 悟、上田 哲大、引網 亮太、村瀬 翔、石井 淳子、河野 智之、星 拓、藤堂 謙一、川本 未知、有吉 孝一、池田 昭夫、幸原 伸夫
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
• [Presentation] VNSの効果作動機構の検討(シンポジウム4) (2015)
  • Author(s): 池田昭夫、Bayasgalan Borgil, 松橋眞生、文室知之、中野直樹、飯田幸治、片桐匡弥、松本理器、國枝武治、加藤天美、髙橋良輔
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
  • Invited
• [Presentation] Co-occurrence of slow shifts and high frequency oscillations(HFOs) in invasively recorded, interictal state: Is it called 'Red slow'? (2015)
  • Author(s): Daifu M, Inouchi M, Inoue T, Kanazawa K, Matsuhashi M, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
• [Presentation] 意味認知の機能可塑性：側頭葉腫瘍切除症例における神経心理学的検討 (2015)
  • Author(s): 中江卓郎、國枝武治、松本理器、荒川芳輝、西田誠、稲野理賀、高橋由紀、稲田拓、下竹昭寛、菊池隆幸、吉田和道、高木康志、池田昭夫、宮本享
  • Organizer: 日本脳神経外科学会第74回学術総会
  • Place of Presentation: 札幌（さっぽろ芸術文化の館）
  • Year and Date: 2015-10-14
• [Presentation] Status epilepticus in the elderly in the super-aging society: clinical and EEG features and prognostic factors. (2015)
  • Author(s): Yoshimura H, Matsumoto R, Ishii J, Kono T, Hoshi T, Todo K, Kawamoto M, Ariyoshi K, Ikeda A, Kohara N.
  • Organizer: 31st International Epilepsy Congress
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2015-09-05
  • Int'l Joint Research
• [Presentation] Non-structural evidence of seizure focus: The role of functional imaging. (2015)
  • Author(s): Ikeda A.
  • Organizer: 31st International Epilepsy Congress
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2015-09-05
  • Int'l Joint Research / Invited
• [Presentation] Clinical implications of intraoperative CCEP monitoring in evaluating the white matter functional integrity of the dorsal language network. (2015)
  • Author(s): Matsumoto R, Yamao Y, Kunieda T, Arakawa Y, Shimotake A, Kikuchi T, Shibata S, Inano R, Sawamoto N, Ikeda A, Mikuni N, Miyamoto S.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸(Kobe)神戸コンベンションセンター
  • Year and Date: 2015-07-28
• [Presentation] Kanji word processing in the ventral anterior temporal lobe: a postoperative neuropsychological study in patients with temporal lobe epilepsy. (2015)
  • Author(s): Ota M, Matsumoto R, Shimotake A, Daifu M, Kunieda T, Miyamoto S, Takahashi R, Lambon-Ralph MA, Ikeda A.
  • Organizer: 第38回日本神経科学学会(Neuroscience 2015)
  • Place of Presentation: 神戸(Kobe)神戸コンベンションセンター
  • Year and Date: 2015-07-28
• [Presentation] The when and where of semantics in the anterior temporal lobe: temporal representational similarity analysis of electrocorticogram data. (2015)
  • Author(s): Shimotake A, Chen Y, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Lambon-Ralph MA, Ikeda A.
  • Organizer: 第38回日本神経科学学術大会
  • Place of Presentation: 神戸(Kobe)神戸コンベンションセンター
  • Year and Date: 2015-07-28
• [Presentation] 発作間欠期の徐波と高周波数律動（HFO）の共起：難治部分てんかん患者の皮質脳波の症例検討 (2015)
  • Author(s): 井上岳司、井内盛遠、松橋眞生、松本理器、人見健文、大封昌子、小林勝哉、金澤恭子、下竹昭寛、國枝武治、高橋良輔、池田昭夫
  • Organizer: 第17回日本ヒト脳機能マッピング学会
  • Place of Presentation: 大阪（毎日新聞社 オーバルホール）
  • Year and Date: 2015-07-02
• [Presentation] 行為関連ネットワークの機能分化と症状の解明：皮質電気刺激による研究 Functional mapping of praxis network: Electrical cortical stimulation study. (2015)
  • Author(s): 下竹昭寛、松本理器、小林勝哉、宇佐美清英、國枝武治、三國信啓、宮本亨、高橋良輔、池田昭夫
  • Organizer: 第9回Motor Control 研究会
  • Place of Presentation: 京都(京都大学)
  • Year and Date: 2015-06-26
• [Presentation] Importance of actual recording of very low frequency EEG to evaluate VNS therapy of epilepsy: recovery filter could not augment effective signals. (2015)
  • Author(s): Borgil B, Matsuhashi M, Nakano N, Katagiri M, Kunieda T, Fumuro T, Shimotake A, Matsumoto R, Iida K, Kato A, Takahashi R, Ikeda A.
  • Organizer: Neural Oscillation Conference 2015
  • Place of Presentation: 京都（京都大学百周年時計台記念館）
  • Year and Date: 2015-06-25
• [Presentation] Functional connectivity revealed by Cortico-Cortical Evoked Potentials. (2015)
  • Author(s): Matsumoto R.
  • Organizer: 20th Korean Epilepsy Congress
  • Place of Presentation: Gwangju, South Korea
  • Year and Date: 2015-06-12
  • Int'l Joint Research / Invited
• [Presentation] ヒト脳の機能可塑性：皮質電気刺激・外科的脳切除の観点から (2015)
  • Author(s): 松本理器、國枝武治、池田昭夫
  • Organizer: 第30回日本生体磁気学会大会 シンポジウム2-3
  • Place of Presentation: 旭川(旭川市大雪クリスタルホール)
  • Year and Date: 2015-06-05
  • Invited
• [Presentation] Functional mapping of praxis network: Electrical cortical stimulation study. (2015)
  • Author(s): Shimotake A, Matsumoto R, Kobayashi K, Usami K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟(朱鷺メッセ)
  • Year and Date: 2015-05-20
• [Presentation] Long-term prognosis of smoldering autoimmune encephalitis. (2015)
  • Author(s): Matsumoto R, Kanazawa K, Togawa J, Hikiami R, Inoue T, Kobayashi K, Shimotake A, Sawamoto N, Takahashi R, Ikeda A.
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟（朱鷺メッセ）
  • Year and Date: 2015-05-20
• [Presentation] 高齢者のてんかん重積状態：臨床的特徴と予後因子について (2015)
  • Author(s): 吉村 元、松本 理器、藤原 悟、上田 哲大、村瀬 翔、十河 正弥、石井 淳子、河野 智之、星 拓、藤堂 謙一、川本 未知、幸原 伸夫
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟（朱鷺メッセ）
  • Year and Date: 2015-05-20
• [Presentation] Importance of very low frequency EEG to evaluate VNS therapy of epilepsy. (2015)
  • Author(s): Borgil B, Matsuhashi M, Nakano N, Iida K, Katagiri M, Shimotake A, Matsumoto R, Fumuro T, Kunieda T, Kato A, Takahashi R, Ikeda A.
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟(朱鷺メッセ)
  • Year and Date: 2015-05-20
• [Presentation] 皮質電気刺激によるヒト脳機能ネットワークの探索 (2015)
  • Author(s): 松本理器、山尾幸広、下竹昭寛、國枝武治、池田昭夫
  • Organizer: 第35回日本脳神経外科コングレス総会、第29回微小脳神経外科解剖研究会合同セッション:脳機能解剖の多次元解析
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2015-05-08
  • Invited
• [Presentation] 発作周辺期の徐波と高周波数律動（HFO）の共起：難治部分てんかん患者の皮質脳波の症例検討 (2014)
  • Author(s): 井上岳司、井内盛遠、松橋眞生、松本理器、人見健文、大封昌子、小林勝哉、金澤恭子、下竹昭寛、國枝武治、高橋良輔、池田昭夫
  • Organizer: 第44回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-11-19 – 2014-11-21
• [Presentation] 発作時DC電位の実際の記録・解析 (2014)
  • Author(s): 金澤恭子、松橋眞生、國枝武治、池田昭夫
  • Organizer: 第44回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-11-19 – 2014-11-21
  • Invited
• [Presentation] てんかん原性のバイオマーカー候補としての高周波律動（HFO）：自発性および刺激誘発性HFOの現状と展望 (2014)
  • Author(s): 小林勝哉、松本理器、松橋眞生、國枝武治、池田昭夫
  • Organizer: 第44回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-11-19 – 2014-11-21
  • Invited
• [Presentation] 皮質・白質電気刺激による高次脳機能ネットワークの術前マッピング (2014)
  • Author(s): 下竹昭寛、松本理器、山尾幸広、國枝武治、池田昭夫
  • Organizer: 第44回日本臨床神経生理学会・学術大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-11-19 – 2014-11-21
  • Invited
• [Presentation] Single Pulse Electrical Stimulation to Probe Human Brain Connectivity and Epileptogenicity (2014)
  • Author(s): Matsumoto R
  • Organizer: Epilepsy Grand Round (by the George Washington University Epilepsy Center)
  • Place of Presentation: Washington D.C. (USA)
  • Year and Date: 2014-11-18
  • Invited
• [Presentation] Functional connectivity of the human entorhinal cortex: a cortico-cortical evoked potential study (2014)
  • Author(s): Takeyama H, Matsumoto R, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: Neuroscience 2014 (Society for Neuroscience annual meeting)
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Imaging Functional and Epileptic Networks with Cortical Stimulation (2014)
  • Author(s): Matsumoto R
  • Organizer: 7th International Workshop on Advances in Electrocorticography
  • Place of Presentation: Washington D.C.（USA)
  • Year and Date: 2014-11-13 – 2014-11-14
  • Invited
• [Presentation] 前頭葉てんかんと睡眠異常 Frontal lobe epilepsy and sleep disorders (2014)
  • Author(s): 松本理器、宇佐美清英、國枝武治、池田昭夫
  • Organizer: 第48回日本てんかん学会学術集会（東京）
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-10-02 – 2014-10-03
  • Invited
• [Presentation] Functional connectivity from the human entorhinal cortex: a corticocortical evoked potential study (2014)
  • Author(s): Takeyama H, Matsumoto R, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第37回日本神経科学学会Neuroscience 2014
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-09 – 2014-09-13
• [Presentation] Dynamic modulation of inter-areal neuronal integrity during sleep: direct evidence from high frequency activities induced by direct cortical stimulation in humans (2014)
  • Author(s): Usami K, Matsumoto R, Hitomi T, Kobayashi K, Shimotake A, Kikuchi T, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Organizer: 第37回日本神経科学学会Neuroscience 2014
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-09 – 2014-09-13
• [Presentation] Slow cortical potential shift as a candidate marker for the efficacy of vagus nerve stimulation for seizure suppression (2014)
  • Author(s): Borgil B, Matsuhashi M, Nakano N, Iida K, Shimotake A, Matsumoto R, Fumuro T, Kunieda T, Kato A, Takahashi R, Ikeda A
  • Organizer: 第37回日本神経科学学会Neuroscience 2014
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-09 – 2014-09-13
• [Presentation] Intracranially-recorded ictal direct current shifts may precede high frequency oscillations in human epilepsy (2014)
  • Author(s): Kanazawa K, Matsumoto R, Imamura H, Matsuhashi M, Kikuchi T, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第37回日本神経科学学会Neuroscience 2014
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-09 – 2014-09-13
• [Presentation] ヒトてんかん病態での自発・誘発脳律動現象 (2014)
  • Author(s): 松本理器、國枝武治、池田昭夫
  • Organizer: 第37回日本神経科学学会Neuroscience 2014
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-09 – 2014-09-13
  • Invited
• [Presentation] Reducing morbidity and mortality in the epilepsy monitoring unit (2014)
  • Author(s): Matsumoto R
  • Organizer: 第10回アジアオセアニアてんかん学会
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2014-08-07 – 2014-08-10
  • Invited
• [Presentation] Oscillatory response in CCEP (2014)
  • Author(s): Nakae T, Matsumoto R, Kunieda T, Matsuhashi M, Shimotake A, Usami K, Kobayashi K, Kikuchi T, Shibata S, Inano R, Nishida S, Fukuyama H, Ikeda A, Miyamoto S
  • Organizer: Neural Oscillation Conference 2014
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県岡崎市)
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] Subcortical network involved in gelastic seizure: an EEG-fMRI study (2014)
  • Author(s): Usami K, Matsumoto R, Sawamoto N, Murakami H, Inouchi M, Fumuro T, Shimotake A, Kato T, Mima T, Masuda H, Fukuyama H, Kameyama S, Takahashi R, Ikeda A
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-05-21 – 2014-05-24
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy: Chapter 36 Cortico-cortical evoked potential mapping (Section 5: Human Brain Mapping). (2016)
  • Author(s): Matsumoto R, Kunieda T.
  • Publisher: Oxford University Press, London
• [Book] 神経内科シリーズ４、てんかん外来（辻貞俊編）：診断に必要な検査．II外来診察の基本的な流れ (2016)
  • Author(s): 吉村 元、松本理器
  • Total Pages: 232
  • Publisher: メジカルビュー社
• [Book] ここが知りたい！臨床神経生理：意識障害 (2016)
  • Author(s): 十川純平、松本理器
  • Publisher: 中外医学社
• [Book] ここが知りたい！臨床神経生理：脳死．脳波 (2016)
  • Author(s): 大封昌子、松本理器
  • Publisher: 中外医学社
• [Book] 臨床てんかん学：5. 頭頂葉てんかん．D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群 (2015)
  • Author(s): 下竹昭寛、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] 臨床てんかん学：1. 側頭葉てんかん. D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群 (2015)
  • Author(s): 井内盛遠、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] 臨床てんかん学：2. 前頭葉てんかん（ジャクソン発作を除く）．D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群 (2015)
  • Author(s): 宇佐美清英、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] 臨床てんかん学：4. Jackson発作関連てんかん．D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群 (2015)
  • Author(s): 芝田純也、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] 臨床てんかん学：3. 後頭葉てんかん．D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群 (2015)
  • Author(s): 金澤恭子、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy (2015)
  • Author(s): Matsumoto R, Kunieda T
  • Publisher: Oxford University Press
• [Book] 神経救急・脳神経外科周術期におけるてんかん発作の管理・ホスフェニトインによる実践集 (2015)
  • Author(s): 下竹昭寛、松本理器
  • Total Pages: 224
  • Publisher: ライフ・サイエンス
• [Book] 神経内科研修ノート (2015)
  • Author(s): 井上岳司、松本理器、池田昭夫
  • Total Pages: 736
  • Publisher: 診断と治療社
• [Book] 睡眠とてんかん その密接な関連性 (2015)
  • Author(s): 宇佐美清英、松本理器、池田昭夫
  • Total Pages: 103
  • Publisher: ライフ・サイエンス
• [Book] 臨床てんかん学 (2015)
  • Author(s): 金澤恭子、松本理器
  • Publisher: 医学書院
• [Book] 臨床てんかん学 (2015)
  • Author(s): 芝田純也、松本理器
  • Publisher: 医学書院
• [Book] 臨床てんかん学 (2015)
  • Author(s): 井内盛遠，松本理器
  • Publisher: 医学書院
• [Book] 脳神経外科医のための脳機能と局在診断 (2014)
  • Author(s): 松本理器
  • Total Pages: 348
  • Publisher: 文光堂
• [Book] 症例から学ぶ戦略的てんかん診断・治療 (2014)
  • Author(s): 松本理器
  • Total Pages: 242
  • Publisher: 南山堂
• [Book] てんかん専門医ガイドブック てんかんにかかわる医師のための基本知識 (2014)
  • Author(s): 松本理器
  • Total Pages: 320
  • Publisher: 診断と治療社
• [Book] カンデル神経学（日本語翻訳版） (2014)
  • Author(s): 山尾幸広、芝田純也、宇佐美清英、松本理器
  • Total Pages: 1696
  • Publisher: メディカル・サイエンス・インターナショナル
• [Remarks] 京都大学大学院医学研究科てんかん・運動異常生理学講座webpage（研究：日本語）
  • URL: http://epilepsy.med.kyoto-u.ac.jp/research
• [Remarks] 京都大学大学院医学研究科てんかん・運動異常生理学講座webpage（研究：英語）
  • URL: http://epilepsy.med.kyoto-u.ac.jp/research_en
• [Remarks] 京都大学大学院医学研究科てんかん・運動異常生理学
  • URL: http://epilepsy.med.kyoto-u.ac.jp/results-3