| Project/Area Number |
26560469
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Brain biometrics
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| Research Institution | Keio University |
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Principal Investigator |
Sugiura Yuki 慶應義塾大学, 医学部(信濃町), 講師 (30590202)
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| Co-Investigator(Renkei-kenkyūsha) |
Norio Takata 慶應義塾大学, 医学部, 特任講師 (50415212)
Kenji Tanata 慶應義塾大学, 医学部, 准教授 (30329700)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脳代謝 / イメージング質量分析 / fMRI / グルコース代謝 |
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| Outline of Final Research Achievements |
In response to a stimuli, neurons and astrocytes alter their metabolic pathways to fit their elevated energy demands. For example, it is known that a stimulation to an animal increase the amount of glucose consumption in the brain region specific manner. To understand molecular mechanism of this phenomenon, a molecular imaging approach is effective. In this research, we developed the novel flux analysis using stable isotopes in combination with MALDI- imaging mass spectrometry, as well as quantitative metabolomics. Those lead us to answer the questions including “during a neural stimulation, in what anatomical regions of the brain, is which metabolic derangement occurring?”. We finally identified a novel metabolic mediator shuttled between neurons and astrocytes up on the stimulation.
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