The association among pre-term infants' DNA polymorphism/methylation, attachment formation and later outcomes

Research Project

Project/Area Number	26590152
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Educational psychology
Research Institution	Tsurumi Junior College
Principal Investigator	SAITO Akira 鶴見大学短期大学部, 保育科, 准教授 (10225691)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000) Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	アタッチメント / DNA多型・メチル化 / ＤＮＡ多型・メチル化 / 早産児
Outline of Final Research Achievements	Neither DRD4/5-HTTLPR polymorphism nor DRD4/SLC6A4 methylation ratio were not associated with gestational age. Multiple regression analysis yielded no association between dependent variables (i.e. NBAS, maternal sensitivity, DRD4/5-HTTLPR polymorphism, DRD4/SLC6A4 methylation ratio) and an independent variable (i.e. disorganized/disoriented score). Mann-Whitney U test revealed the highest disorganized/disoriented score group against the lowest one showed significantly higher methylation ratio at certain SLC6A4 CpG sites.