| Project/Area Number |
26600059
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nano/Microsystems
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
Takamura Yuzuru 北陸先端科学技術大学院大学, 先端科学技術研究科, 教授 (20290877)
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| Co-Investigator(Kenkyū-buntansha) |
浮田 芳昭 山梨大学, 大学院総合研究部, 助教 (40578100)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 質量分析 / タンパク質のイオン化 / MALDI / 熱パルスイオン化 / マトリックスフリー / 糖のイオン化 / イオン化メカニズム / マイクロ流体デバイス / ＭＡＬＤＩ / ＴＯＦ / マイクロデバイス / BioMEMS / 微量分析 / 血液分析 / time of flight |
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| Outline of Final Research Achievements |
This research tried to miniaturize mass spectroscopy on a chip. Especially, pulse heating ionization and dissociation method (PHDI) was developed. In this method, samples were ionized and dissociated by a heat pulse generated by micro heater on chip. PHDI was found to be a novel ionization method with extremely excellent properties that PHDI not always requires matrix assist for ionization and can ionize wide range of materials from inorganic to macromolecule, including proteins, hydrocarbons and sugars, with very high efficiency and qualities of soft-ionization.
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