Development of 3-dimensional-structure sensors with molecular-level resolution and their application to solid/liquid interface analysis on biocells.
| Project/Area Number |
26600065
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nano/Microsystems
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
柳沢 雅広 早稲田大学, ナノ・ライフ創新研究機構, 客員上級研究員(研究院客員教授) (20421224)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 表面・界面 / プラズモニクス / 表面増強ラマン散乱 / 細胞表面 / ナノ・マイクロファブリケーション / 固液界面 / マイクロ・ナノファブリケーション |
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| Outline of Final Research Achievements |
A novel measurement tool, which is capable to analyze chemical structures of ultra-thin films or interfaces, has been developed, based on surface enhanced Raman scattering with newly developed “plasmon sensors,” which enhances local intensity of the Raman signals. Various types of the plasmon sensors have been developed, and as a result, ultra-thin organic films, i.e. self-assembled monolayers, lipid bilayers, cell membranes, were successfully analyzed. Particularly, inner chemical structure of the films was measured with a depth resolution of 0.1nm. Developed methodology is expected to apply wide areas such as diagnostics of various types of cells (e.g., cancer cells) as well as fundamental researches for biomedical field.
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Report
(4 results)
Research Products
(15 results)
