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Development of 3-dimensional-structure sensors with molecular-level resolution and their application to solid/liquid interface analysis on biocells.

Research Project

Project/Area Number 26600065
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nano/Microsystems
Research InstitutionWaseda University

Principal Investigator

HOMMA Takayuki  早稲田大学, 理工学術院, 教授 (80238823)

Co-Investigator(Kenkyū-buntansha) 柳沢 雅広  早稲田大学, ナノ・ライフ創新研究機構, 客員上級研究員(研究院客員教授) (20421224)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords表面・界面 / プラズモニクス / 表面増強ラマン散乱 / 細胞表面 / ナノ・マイクロファブリケーション / 固液界面 / マイクロ・ナノファブリケーション
Outline of Final Research Achievements

A novel measurement tool, which is capable to analyze chemical structures of ultra-thin films or interfaces, has been developed, based on surface enhanced Raman scattering with newly developed “plasmon sensors,” which enhances local intensity of the Raman signals. Various types of the plasmon sensors have been developed, and as a result, ultra-thin organic films, i.e. self-assembled monolayers, lipid bilayers, cell membranes, were successfully analyzed. Particularly, inner chemical structure of the films was measured with a depth resolution of 0.1nm. Developed methodology is expected to apply wide areas such as diagnostics of various types of cells (e.g., cancer cells) as well as fundamental researches for biomedical field.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results)

  • [Journal Article] Depth profiling of APTES self-assembled monolayers using surface-enhanced confocal Raman microspectroscopy2017

    • Author(s)
      Y. Sun, M. Yanagisawa, M. Kunimoto, M. Nakamura, T. Homma
    • Journal Title

      Spectrochimica Acta Part A

      Volume: 184 Pages: 1-6

    • DOI

      10.1016/j.saa.2017.04.036

    • NAID

      130005481010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Estimated Phse Transition and Melting Temperature of APTES Self-assembled Monolayer using Surface-enhanced Anti-Stokes and Stokes Raman Scattering2016

    • Author(s)
      Y. Sun, M. Yanagisawa, M. Kunimoto, M. Nakamura, T.Homma
    • Journal Title

      Applied Surface Science

      Volume: 363 Pages: 572-577

    • DOI

      10.1016/j.apsusc.2015.12.035

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] CHO-K1生細胞の透過型プラズモンセンサを用いた表面増強ラマン分光計測の試み2017

    • Author(s)
      荒原涼人, Morten Bertz, 柳沢雅広, 本間敬之
    • Organizer
      電気化学会第84回大会
    • Place of Presentation
      東京
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Theoretical and in situ SERS analysis on the electrochemical micro/nano fabrication processes2016

    • Author(s)
      T. Homma
    • Organizer
      5th International Symposium on Materials Science and Surface Technology
    • Place of Presentation
      Yokohma, Japan
    • Year and Date
      2016-08-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シリカチューブアレイ構造を用いた透過型プラズモンセンサ作製の試み2016

    • Author(s)
      佐藤祐太,中村雅俊,柳沢雅広,本間敬之
    • Organizer
      表面技術協会第133回講演大会
    • Place of Presentation
      東京
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 固液界面のin situラマン解析を目的としたpoly(dimethylsiloxane)製プラズモンセンサの開発2016

    • Author(s)
      中村雅俊, 佐藤祐太, 柳沢雅広, 本間敬之
    • Organizer
      表面技術協会第133回講演大会
    • Place of Presentation
      東京
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Study on chemical structure inside APTES SAMs by using SERS: depth profile and phase transition process2015

    • Author(s)
      Y. Sun, M. Yanagisawa, M. Kunimoto, M. Nakamura, T. Homma
    • Organizer
      第5回CSJ化学フェスタ
    • Place of Presentation
      東京
    • Year and Date
      2015-10-13
    • Related Report
      2015 Research-status Report
  • [Presentation] In situ Analysis of Electrochemical Fabrication Processes Using Raman Spectroscopy with Plasmonic Sensors2015

    • Author(s)
      T. Homma, Y. Sun, M. Kunimoto, M. Saito, M. Yanagisawa
    • Organizer
      66thMeeting of the International Society of Electrochemistry
    • Place of Presentation
      Taipei
    • Year and Date
      2015-10-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Nano-contact Analysis using Plasmonic Sensors2015

    • Author(s)
      M.Yanagisawa, M.Kunimoto and T.Homma
    • Organizer
      ITC, Tokyo 2015
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 表面増強ラマン測定による電極界面水素イオン濃度解析の試み2015

    • Author(s)
      佐々木萌,花井智也,國本雅宏,柳沢雅広,本間敬之
    • Organizer
      2015年度電気化学秋季大会
    • Place of Presentation
      埼玉
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 電極界面におけるpH測定系の開発に向けた理論的検討2015

    • Author(s)
      花井智也,佐々木萌、國本雅宏,柳沢雅広、中井浩巳,本間敬之
    • Organizer
      表面技術協会第132回講演大会
    • Place of Presentation
      長野
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規な電気化学的ナノ構造形成プロセスの開拓と実践2015

    • Author(s)
      本間敬之
    • Organizer
      電気化学会第82回大会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-03-15
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ゾルゲル法と電解析出法による透過型プラズモンセンサの作製2015

    • Author(s)
      齋藤美紀子, 三田正弘, 柳沢雅広, 本間敬之
    • Organizer
      表面技術協会 第131回講演大会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-03-04
    • Related Report
      2014 Research-status Report
  • [Presentation] In-situ temperature measurements on the phase change point of monolayer APTES by Surface-enhanced anti-Stokes and Stokes Raman Scattering2014

    • Author(s)
      Y.Sun, M.Yanagisawa, M.Kunimoto, and T.Hommma
    • Organizer
      7th International Symposium on Surface Science (ISSS-7)
    • Place of Presentation
      Matsue, Japan
    • Year and Date
      2014-11-06
    • Related Report
      2014 Research-status Report
  • [Presentation] In Situ Surface Enhanced Raman Spectroscopy Analysis of the Electrochemical Deposition Processes Using Plasmon Antenna Sensors2014

    • Author(s)
      T. Homma, T. Yamamoto, M. Nakamura, M. Kunimoto, M. Saito, M. Yanagisawa
    • Organizer
      2014 ECS & SMEQ Joint International Meeting
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      2014-10-08
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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