Development of nondestructive AFM method and its application for investigation of biomolecular structures

• Project/Area Number: 26600097
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Thin film/Surface and interfacial physical properties
• Research Institution: Kanazawa University
• Principal Investigator: Asakawa Hitoshi 金沢大学, 物質化学系, 准教授 (90509605)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 原子間力顕微鏡 / ナノテクノロジー / プローブ顕微鏡

Outline of Final Research Achievements

In this project, I developed an atomic force microscopy (AFM) method that was capable to detect nanostructures existing in the horizontal direction of an AFM probe in non-contact manner. The detection of nanostructures became possible by a simultaneous excitation and monitoring of two vibration modes of cantilevers used as a force sensor. The two vibration modes are the vertical normal bending and the torsional bending vibrations. The practicality of the developed AFM method can be improved by optimizing the cantilever shape and establishing the feedback control conditions.

Research Products

• [Presentation] 液中原子分解能AFMによるテトラフェニルメタン骨格分子の自己組織化および単一分子内三脚構造の可視化 (2017)
  • Author(s): 松井彩香、太田明雄、淺川毅、淺川雅
  • Organizer: 日本化学会 第97春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
  • Year and Date: 2017-03-16
• [Presentation] Linear assembly of tetraphenylmethane derivatives investigated by AFM (2016)
  • Author(s): Sayaka Matsui, Akio Ohta, Tsuyoshi Asakawa and Hitoshi Asakawa
  • Organizer: 2nd International Symposium on Center of Excellence for Innovative Material Sciences Based on Supramolecules
  • Place of Presentation: 石川県金沢市
  • Year and Date: 2016-10-26
  • Int'l Joint Research
• [Presentation] Molecular-scale Investigation of Sulfonate-terminated Alkanethiol SAMs by FM-AFM in Liquid (2016)
  • Author(s): Natsumi Inada, Hitoshi Asakawa, Norihisa Oku, Takeshi Fukuma
  • Organizer: 19th International Conference on non-contact Atomic Force Microscopy
  • Place of Presentation: Nottingham, UK
  • Year and Date: 2016-07-25
  • Int'l Joint Research
• [Presentation] 液中原子分解能を有する原子間力顕微鏡による固液界面計測 (2016)
  • Author(s): 淺川雅
  • Organizer: 電子情報通信学会有機エレクトロニクス研究会
  • Place of Presentation: 石川県金沢市
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] ３次元走査型力顕微鏡による揺動するナノ分子鎖の液中実空間計測 (2016)
  • Author(s): 稲田なつみ、高尾一史、淺川雅、福間剛士
  • Organizer: 第６３回応用物理学会春季学術講演会
  • Place of Presentation: 東京工業大学大岡山キャンパス
  • Year and Date: 2016-03-19
• [Presentation] ３次元走査型原子間力顕微鏡を用いた固液界面に存在するナノ分子鎖の実空間計測 (2016)
  • Author(s): 高尾一史、淺川雅、稲田なつみ、福間 剛士
  • Organizer: 第２５回インテリジェント材料・システムシンポジウム
  • Place of Presentation: 東京女子医科大学先端生命医科学研究所
  • Year and Date: 2016-01-08
• [Presentation] Spatial distribution of nanoscale flexible chains as a protein terminal model visualized by 3D scanning force microscopy (2015)
  • Author(s): H. Asakawa, K. Takao, N. Inada and T. Fukuma
  • Organizer: The International Chemical Congress of Pacific Basin Societies 2015
  • Place of Presentation: Hawaii, U.S.A
  • Year and Date: 2015-12-15
  • Int'l Joint Research