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Plasma-on-Chip

Research Project

Project/Area Number 26600130
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Plasma electronics
Research InstitutionToyota Technological Institute

Principal Investigator

Kumagai Shinya  豊田工業大学, 工学部, 准教授 (70333888)

Co-Investigator(Kenkyū-buntansha) SASAKI Minoru  豊田工業大学, 工学部, 教授 (70282100)
JEONG Jonghyon  豊田工業大学, 工学部, 研究員 (90728114)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsプラズマ / 細胞 / MEMS / プラズマ医療 / 低温大気圧プラズマ
Outline of Final Research Achievements

Our objective is to irradiate a single cell with an atmospheric pressure plasma for controlling biological activity of the single cell. Using technologies of plasma and micro electromechanical systems (MEMS), we have developed a microdevice which enabled plasma irradiation to a single cell. The microdevice was named as “Plasma-on-Chip”. In the plasma irradiation, reactive species generated in the plasma were delivered to a single cell cultured in a microwell through through-holes fabricated in the microwell bottom. We used Chlorella cell for the biological experiments. The plasma irradiation decreased fluorescence from the Chlorella cells. It was considered that the reactive species degraded biological activity of the Chlorella cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 3 results) Remarks (4 results)

  • [Int'l Joint Research] terraplasma, GmbH(Germany)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Development of plasma-on-chip: Plasma treatment for individual cells cultured in media2016

    • Author(s)
      S. Kumagai, C.-Y. Chang, J.-H. Jeong, M. Kobayashi, T. Shimizu, M. Sasaki
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 1S Pages: 01AF01-01AF01

    • DOI

      10.7567/jjap.55.01af01

    • NAID

      210000145988

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Plasma-on-chip device for stable irradiation of cells cultured in media with a low-temperature atmospheric pressure plasma2016

    • Author(s)
      T. Okada, C.-Y. Chang, M. Kobayashi, T. Shimizu, M. Sasaki, S. Kumagai
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: in press Pages: 11-18

    • DOI

      10.1016/j.abb.2016.04.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Measurement of Reactive Species for the Development of Plasma-on-Chip2016

    • Author(s)
      J.-S. Oh, S. Kojima, A. Hatta, M. Sasaki, S. Kumagai
    • Organizer
      2016年春季応用物理学会
    • Place of Presentation
      東京工業大学 大岡山キャンパス (東京都・目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Plasma-on-chip: Plasma-on-Chip: Evidence of Reactive Species Through Through-Holes2016

    • Author(s)
      J.-S. Oh, S. Kojima, A. Hatta, M. Sasaki, S. Kumagai
    • Organizer
      ISPlasma 2016/IC-PLANTS 2016
    • Place of Presentation
      Nagoya University, Nagoya, Japan
    • Year and Date
      2016-03-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasma-on-chip device for analyzing interactions between plasma gas and individual cells2015

    • Author(s)
      C.-Y. Chang, J.-H. Jeong, M. Kobayashi, T. Shimizu, M. Sasaki, S. Kumagai
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Irradiating cells cultured in microwells with low-temperature atmospheric pressure plasma2015

    • Author(s)
      C.-Y. Chang, J.-H. Jeong, M. Kobayashi, T. Shimizu, M. Sasaki, S. Kumagai
    • Organizer
      he 10th Asian-Europian International Conference on Plasma Surface Engineering (AEPSE2015)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasma-on-Chip for Treatment of Individual Cells Cultured in Medium2015

    • Author(s)
      C.-Y. Chang, J.-H. Jeong, M. Kobayashi, T. Shimizu, M. Sasaki, S. Kumagai
    • Organizer
      2015年秋季応用物理学会
    • Place of Presentation
      名古屋国際会議場 (愛知県・名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Plasma-on-Chip for Controlling Bioreaction of an Individual Cell2015

    • Author(s)
      CHUN-YAO CHANG, JONGHYEON JEONG, MIME KOBAYASHI, TETSUJI SHIMIZU, MINORU SASAKI, SHINYA KUMAGAI
    • Organizer
      ISPlasma 2015 / IC-PLANTS 2015
    • Place of Presentation
      Nagoya University
    • Year and Date
      2015-03-26 – 2015-03-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Plasma-on-Chip: Plasma Treatment of Individual Cells using Gas-Liquid Interface2015

    • Author(s)
      C.-Y. Chang, J.-H. Jeong, M. Kobayashi, T. Shimizu, M. Sasaki, S. Kumagai
    • Organizer
      2015年 春季応用物理学会
    • Place of Presentation
      東海大学
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Remarks] 豊田工業大学 マイクロメカトロニクス 研究室 ホームページ

    • URL

      http://www.toyota-ti.ac.jp/mems/index.htm

    • Related Report
      2015 Annual Research Report
  • [Remarks] 豊田工業大学 研究者 一覧 マイクロメカトロニクス研究室 准教授 熊谷慎也

    • URL

      http://ttiweb.toyota-ti.ac.jp/public/user.php

    • Related Report
      2015 Annual Research Report
  • [Remarks] 豊田工業大学 マイクロメカトロニクス 研究室

    • URL

      http://www.toyota-ti.ac.jp/mems/index.htm

    • Related Report
      2014 Research-status Report
  • [Remarks] 豊田工業大学 研究者 一覧

    • URL

      http://ttiweb.toyota-ti.ac.jp/public/user.php

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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