Simulations of tumor grawth with cell division
| Project/Area Number |
26610131
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MOLINA John 京都大学, 大学院工学研究科, 助教 (20727581)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | シミュレーション / アクティブマター / 細胞遊走 / 生体組織 / 細胞分裂 / 腫瘍 |
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| Outline of Final Research Achievements |
We developed a cell model by connecting multiple particles with springs that can be applicable for crawling cells on a substrate by changing their shapes. The effects of cell contraction due to myosin and cell adhesion due to adhesive proteins against the substrate are implemented into the model. Furthermore, the spatio-temporal evolutions of the densities of myosin and PIP3 molecules have been resolved by using a reaction-diffusion equation on cell membrane. The present model allows us to bridge between different scales from molecules to shape change of cells.
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Report
(4 results)
Research Products
(17 results)
