| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Asymmetric nitrene transfer reaction is one of most efficient and ideal tools for the synthesis of chiral nitrogen containing compounds. Recently, we found that azide compound is an efficient nitrene precursor in enantioselective amino functionalization. (OC)ruthenium-salen complexes can decompose azide compounds to corresponding nitrene intermediates with co-producing nitrogen gas as by-product and introduce nitrogen function group with excellent enantioselectivity under ambient conditions without any activation methods such as heating and photo-irradiation.
The author has started mechanistic studies of ruthenium-catalyzed C-H amination. Based on these studies, our group disclosed the nitrene C-H insertion proceeded via rate-determining hydrogen atom abstraction and related radical-radical re-bonding. The author believed that this knowledge is an important for the progress of sustainable organic synthesis.
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