Constructions of supramolecular metal-free MRI contrast agents showing a higher sensitivity
| Project/Area Number |
26620070
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional solid state chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
HAGIHARA Ryusuke 九州大学, 大学院薬学府
OKAMOTO Yuna 九州大学, 大学院薬学研究院, 技術補佐員
ARAKI Takeru 九州大学, 大学院薬学府
MORISHITA Kosuke 九州大学, 大学院薬学府
SHIRAISHI Ryoma 九州大学, 薬学部
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MRI / 造影剤 / ラジカル / ナノ微粒子 / がん / 自己集合化 / がん診断 / メタルフリー / TEMPO / 超分子 / 蛍光イメージング |
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| Outline of Final Research Achievements |
MRI contrast agents used in clinical are containing metals such as Gadolinium. Due to influences of the metal ion, the contras agents often show significant side effects. In order to This time, we developed the metal free contrast agents using organic radicals. However, the contrast agents containing organic radicals exhibit smaller sensitivity than that of metal contrast agents because of smaller spin quantum number. Accordingly, to overcome the disadvantage of the metal free contrast agents and enhance the sensitivity, we used nanoparticles possessing organic radical (RNP). As the results, the RNP showed higher sensitivity than that of radicals consisted of smaller molecules. Furthermore, we successfully prepared the RNP possessing a pH responsiveness. Tumor tissues show the acidic microenvironment than that of normal tissues. Thus, in the future, we will prepare the metal free contrast agent capable of being in response to the tumor that have acidic microenvironment.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Rational syntheses of helical pai-conjugated oligopyrrins with a bipyrrole linkage: geometry control of bis-copper(II) coordination2016
Author(s)
Kai Zhang, Mathew Savage, Xin Li, Yu Jiang, Masatoshi Ishida, Koki Mitsuno, Satoru Karasawa, Tatsuhisa Kato, Weihua Zhu, Sihai Yang, Hiroyuki Furuta and Yongshu Xie
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Journal Title
Chem. Commun.
Volume: 52
Issue: 29
Pages: 5148-5151
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] One-, Two-, and Three-Dimensional Heterospin Complexes Consisting of 3d Metal Ions, 4-(N-tert-Butyloxylamino)pyridine (4NOpy), and Dicyanamide ion (DCA); Crystal Structures and Magnetic Properties of [MII(4NOpy)x(DCA)y(CH3CN)z]n: MII = Mn, Co, Ni, Cu, and Zn2016
Author(s)
Hiraku Ogawa, Koya Mori, Kensuke Murashima, Satoru Karasawa, and Noboru Koga
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Journal Title
Inorg. Chem.
Volume: 55
Issue: 2
Pages: 717-728
DOI
Related Report
Peer Reviewed
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[Journal Article] Stable π-Radical from a Contracted Doubly N-Confused Hexaphyrin by Bis-Palladium Metallation2015
Author(s)
Y. Hisamune, K. Nishimura, K. Isakari, M. Ishida, S. Mori, Satoru. Karasawa, T. Kato, Sangsu L., D.Kim, and H. Furuta,
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Journal Title
Angew. Chem., Int. Ed. Engl.
Volume: 54
Issue: 25
Pages: 7323-7327
DOI
Related Report
Peer Reviewed
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[Journal Article] Magnetic Properties of 1:2 Mixed Cobalt(II) Salicylaldehyde Schiff-Base Complexes with Pyridine Ligands Carrying High-Spin Carbenes (Scar = 2/2, 4/2, 6/2, and 8/2) in Dilute Frozen Solutions: Role of Organic Spin in Heterospin Single-Molecule Magnets2014
Author(s)
Satoru Karasawa, Kimihiro Nakano, Daisuke Yoshihara, Noriko Yamamoto, Jun-ichi Tanokashira, Takahito Yoshizaki, Yuji Inagaki, Noboru Koga
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Journal Title
Inorg Chem.
Volume: 53
Issue: 11
Pages: 5447-5457
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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