Catalytic Asymmetric Synthesis of Phosphine Derivatives with a Stereogenic Phosphorus Atom
| Project/Area Number |
26620074
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 触媒的不斉合成 / リン / 中心不斉 / メタセシス / 非対称化 / モリブデン / クロム / 不斉合成 / ホスフィン / 閉環メタセシス |
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| Outline of Final Research Achievements |
We have achieved the formal asymmetric cross-metathesis between an alkenylbenzene derivative and a bis(methallyl)phosphine by the use of a chiral molybdenum-alkylidene catalyst giving the phosphine drivative with a stereogenic phosphorus atom in up to 95% ee. Our strategy is the use of a chromium fragment as a template, in which the two reactants are preinstalled onto the chromium metal. The chromium complexes thus obtained were employed as substrates for the asymmetric ring-closing metathesis and the subsequent de-chromation reaction afforded the acyclic metal-free phosphine derivatives with the perfect chemo-selectivity and the Z-selectivity.
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Report
(3 results)
Research Products
(18 results)
