| Project/Area Number |
26620082
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kwansei Gakuin University (2015)
Kyoto University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ラジカル反応 / 芳香族置換反応 / 有機合成化学 |
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| Outline of Final Research Achievements |
Utilizing homolytic aromatic substitution mechanism consisting of addition of a radical species to aromatic rings and elimination of another radical species, we have accomplished, with the aid of tert-butoxy radical precursors, the dehydrogenative coupling between amides/ureas/ethers and benzene derivatives as well as the alpha-arylation of amines with aryl halides or sulfones. A simple reduction system of aryl halides consisting of cesium carbonate, isopropyl alcohol and a tert-butoxy radical precursor also has been developed.
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