| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In order to improve the practicality and efficiency of the transition-metal catalyzed C-H bond functionalization reaction, new catalytic reactions that consist of the introduction of an activating group into an organic molecule, the bond formation reaction, and recycle of the activating group, were investigated. As the result, unexpected effect of salicylaldehyde which act as the multipurpose directing group that is easily available, installable, removable, and recoverable, for palladium-catalyzed arylation reaction of primary amines was developed. In addition, a palladium-catalyzed intramolecular insertion of alkenes into carbonyl C-N bonds of β-lactams affording nitrogen-containing fused bicyclic compounds was discovered.
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