| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Outline of Final Research Achievements |
Transition metal catalyzed enantioselective cross-coupling reactions of organic halides with organometallics are powerful tool in asymmetric synthesis of chiral functional organic molecules. In combination with chiral ligands of appropriate choice, palladium and nickel catalysts have proved particularly useful. On the other hand, the most synthetically attractive transition metal, iron, have not yet been utilized as catalyst in the asymmetric cross-coupling reaction despite the remarkable progress of the iron-catalyzed cross-coupling reactions in the last decade. We have developed the first iron-catalyzed asymmetric cross-coupling reactions of α-haloalkanoates with ArMgBr using a catalytic amount of an iron salt and a chiral bisphosphine ligand, BenzP*, giving the products in high yields with good enantioselectivities. The developed asymmetric coupling offers and practical access to various chiral α-arylalkanoic acids derivatives, which are of significant pharmaceutical importance.
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