| Project/Area Number |
26620086
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
TOBISU Mamoru 大阪大学, 工学(系)研究科(研究院), 准教授 (60403143)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 均一系触媒反応 / π共役化合物 / クロスカップリング / リン化合物 / π共役系化合物 |
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| Outline of Final Research Achievements |
To establish robust synthetic strategy to rapidly increase both complexity and diversity of pai-conjugated compounds, the following investigation has been performed. 1) Catalytic construction of pai-conjugated scaffold: Compared to phosphorus-linked biaryl compounds (i.e., phosphole), the corresponding six-membered phophacycles (phosphorus-bridged biaryl ether or amine) are less explored, especially in terms of their catalytic synthesis. Our newly developed cyclization method via C-P bond cleavage has successfully been applied to the synthesis of polyannulated six-membered phosphacycles. 2) Late stage functionalization of pai-conjugated molecules via C-O bond cleavage: In this study, a robust methoxy group is demonstrated to serve as a versatile handle for the introduction of an alkynyl group to siloles, ferrocenes and polyaromatics at the late stage of synthesis by using a nickel-based catalyst. The flexible synthesis of dibenzochrysene was also accomplished.
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