Development of a new strategy toward selective cleavage of unactivated sp3C-H bonds and its application to bond forming reactions
| Project/Area Number |
26620087
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Kambe Nobuaki 大阪大学, 工学(系)研究科(研究院), 教授 (60144432)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炭素―水素結合切断 / 炭素―水素結合官能基化 / カルコゲン / 触媒 / 含窒素複素環 |
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| Outline of Final Research Achievements |
In this study, we developed transition metal-catalyzed sulfenylation, selenylation, and sulfonylation of arenes and heteroarenes through sp2C-H bond cleavage. In addition, we also found that Cu catalyzes intramolecular amination of unactivated sp3C-H bond to give indoline derivatives.
In order to develop a new methodology of C-H bond cleavage without the aid of directing group in substrates, we designed a new rhodium catalyst bearing cyclodextrin moiety, which could capture the substrate in its hydrophobic cavity through supramolecular complexation to facilitate C-H bond cleavage.
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Report
(3 results)
Research Products
(14 results)
