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Nerve cell growth control by cell adhesion peptide nanofibers that regularly arranged on a polymer interface

Research Project

Project/Area Number 26620102
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Polymer chemistry
Research InstitutionKyoto Institute of Technology

Principal Investigator

Tanaka Naoki  京都工芸繊維大学, 分子化学系, 教授 (60243127)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords熱ショック蛋白質 / ペプチド / 細胞培養 / ポリスチレン / 神経細胞 / ペプチドナノファイバー / アミロイド線維 / ポリスチレン基板 / ナノ繊維 / 細胞接着
Outline of Final Research Achievements

A peptide sequence corresponding to the substrate binding site heat shock protein α-crystallin (αAC (71-88)) form a nano fiber that has the ability to adsorb the protein by heat treatment. In this study, new peptide nano fiber with an affinity for hydrophilic polystyrene and cell surface by introducing a lysine and arginine for the amino acid sequence of αAC (71-88). It was designed to cell adhesion to bond the cell and the substrate . By mixing a peptide incorporating the peptide in sequence IKVAV, peptide nanofibers could be promote cell proliferation of PC12, a neuronal cell model.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015

All Presentation (3 results)

  • [Presentation] iPS細胞の万能性を維持するペプチドナノファイバーのラショナルデザイン2015

    • Author(s)
      豊島 明
    • Organizer
      第61回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館
    • Year and Date
      2015-07-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 基質認識配列を置換したナノファイバー化シャペロンペプチドによる培養細胞の分化制御2015

    • Author(s)
      豊島 明,雲 沙也香,和久 友則,須丸 公雄,金森 敏幸,田中 直毅
    • Organizer
      第64回 高分子学会 年次大会
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 基質認識配列を置換したナノファイバー化シャペロンペプチドによる培養細胞の分化制御2015

    • Author(s)
      豊島 明
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-05-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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