Prepration and Function of Dynamic Sulfated Glycopolymers
| Project/Area Number |
26620106
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Polymer chemistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
Miura Yoshiko 九州大学, 工学(系)研究科(研究院), 教授 (00335069)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 糖鎖高分子 / 生体関連高分子 / 分子認識 / 硫酸化糖 / グリコサミノグリカン / ゲル粒子 / ナノゲル |
|---|
| Outline of Final Research Achievements |
Various glycopolymers were prepared with different sugar ratio, density and physical properties. The glycopolymers were prepared as linear polymers, nanogels, and polymer monolith. Not only were the density of sugar, but also physical properties of the glycopolymers important for protein recognition. Target proteins depended on the sugar structure, and sulfated glucosamine bound to the enzyme and growth factors.
The polymer monolith was also prepared with the same method with condensed condition under the mixture of DMSO and alcohol. The glycopolymers with various saccharides were prepred via living radical polymerization and click chemistry.
|
Report
(3 results)
Research Products
(55 results)
