| Project/Area Number |
26620127
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
YAMAMURA Masaki 筑波大学, 数理物質系, 講師 (40524426)
NAKAMURA Takashi 筑波大学, 数理物質系, 助教 (90734103)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | バイオイメージング / 発光性分子 / センサー / 超分子 |
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| Outline of Final Research Achievements |
In fluorescence bioimaging, suitable balance between hydrophilicity and hydrophobicity of a fluorescent molecule is a key to the molecular design. In this study we designed and synthesized cyclodextrin-appended BODIPYs as a fluorescent probe on the basis of concept of a molecular coat. In aqueous media, the hydrophobic BODIPY unit would be captured by the CD in the cavity and in hydrophobic media the host-guest complex would be dissociated to be dissolved. The CD-appended BODIPY is soluble in solvent systems of a wide range of polarity. Spectroscopic examination suggested that the molecular-coat concept probably worked well to provide a new way to very efficient introduction of fluorescent probes into living cells.
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