Development of molecular probes for Raman bioimaging
| Project/Area Number |
26620129
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKAMOTO Akimitsu 東京大学, 先端科学技術研究センター, 教授 (60314233)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | ラマン分光 / 炭素－炭素三重結合 / 細胞イメージング / 刺激応答性 / 炭素-炭素三重結合 |
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| Outline of Final Research Achievements |
The objective of this research is to develop new labeling molecules for Raman bioimaging. Raman spectroscopy is one of the major candidates for gaining the multimodality of bioimaging. We chemically synthesized new labeling agents showing a specific wave number at 2000cm-1, which is not cell-characteristic wave number. These labeling molecules exhibited the Raman signals only when the molecules are activated with external stimulation under a mild condition. Finally, we observed molecular behavior in cells after we labeled the cells with the functional Raman labels tethered to the target biomolecules.
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Report
(2 results)
Research Products
(5 results)
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[Journal Article] FTO-Dependent Demethylation of N6-Methyladenosine Regulates mRNA Splicing and Is Required for Adipogenesis2014
Author(s)
Yang, Y. G.; Zhao, X.; Yang, Y.; Sun, B. F.; Shi, Y.; Yang, X.; Xiao, W.; Hao, Y.; Ping, X.-L.; Chen, Y.; Wang, W.-J.; Jin, K.-X.; Wang, X.; Huang, C.; Fu, Y.; Ge, X.; Song, S.; Jeong, H. S.; Yanagisawa, H.; Niu, Y.; Jia, G.; Wu, W.; Tong, W.-M.; Okamoto, A.; He, C.; Danielsen, J. M.; Wang, X.
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Journal Title
Cell Res.
Volume: 24
Pages: 1403-1419
Related Report
Peer Reviewed
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