Liposomal crosslinker for cell sorting and functional matrix

Research Project

Project/Area Number	26620136
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Bio-related chemistry
Research Institution	Kyushu University
Principal Investigator	Mori Takeshi 九州大学, 工学(系)研究科(研究院), 准教授 (70335785)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	セルソーティング / マトリックス / リポソーム / 抗体 / 細胞外マトリックス
Outline of Final Research Achievements	I studied the usage of antibody-modified liposome for cell sorting and matrix. Epithelia form aggregate not only by liposome but also by endogenous adhesion molecules. On the other hand, I found that floating cell (K562) can not be crosslinked by this method. I attributed this to the dissociation of antibody during cell aggregation process. Thus, I developed new lipid molecule which stable anchor on liposomal membrane. I found that the synthesized lipid was homogenously dispersed in the membrane.

Report

(3 results)