• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Design of beta-sheet inhibitors based on peptide metal complex arrays

Research Project

Project/Area Number 26620139
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bio-related chemistry
Research InstitutionNational Institute for Materials Science

Principal Investigator

TASHIRO KENTARO  国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (40332598)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords多核金属錯体 / ペプチド / 自己集合 / アミロイド / アニオン依存性 / アミロイド阻害 / ペプチド金属錯体 / ホフマイスター系列 / アミロイド阻害剤
Outline of Final Research Achievements

Design of water-soluble peptide metal complex arrays and studies on their self-assembling behaviors revealed their unique dependency on the co-existent anions, which is clearly different from the general tendency of peptides and proteins, known as “Hofmeister series” A water-soluble peptide metal complex array was found to inhibit the amyloid fibril formation of an amyloidogenic peptide and digest its preformed amylid fibers.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Jilin University(中国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A water-soluble metal–organic complex array as a multinuclear heterometallic peptide amphiphile that shows unconventional anion dependency in its self-assembly2016

    • Author(s)
      Pradip K. Sukul, Purnandhu Bose, Toshiaki Takei, Omar M. Yaghi, Ying He, Myongsoo Lee, Kentaro Tashiro*
    • Journal Title

      Chemical Communications

      Volume: 52 Issue: 8 Pages: 1579-1581

    • DOI

      10.1039/c5cc08973e

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Anti-Amyloid Activity of Peptide Metal Complex Arrays2016

    • Author(s)
      田代健太郎
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2016-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Anti-Amyloid Activity of Peptide Metal Complex Arrays2016

    • Author(s)
      田代健太郎
    • Organizer
      第96回春季年会
    • Place of Presentation
      同志社大学
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Solid-Phase Synthesis of Multi-metallated Peptide Arrays and Their Applications for Biomedical Issues2016

    • Author(s)
      田代健太郎
    • Organizer
      Vth National Symposium on Advances in Chemical Sciences
    • Place of Presentation
      Guru Nanak Dev Univ., Amritsar, India
    • Year and Date
      2016-02-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Solid-Phase Synthesis of Multi-metallated Peptide Arrays and Their Applications for Biomedical Issues2015

    • Author(s)
      田代健太郎
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii,Honolulu
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ペプチド固相合成法を利用した金属錯体ネットワークの構築と応用2015

    • Author(s)
      田代健太郎
    • Organizer
      JAIセミナー大阪
    • Place of Presentation
      ブリーゼプラザ 大阪西梅田
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ペプチド固相合成法を利用した金属錯体ネットワークの構築と応用2015

    • Author(s)
      田代健太郎
    • Organizer
      JAIセミナー東京
    • Place of Presentation
      朝日生命ビル 大手町サンスカイルーム
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ペプチド金属錯体アレイの固相合成と生物医学的応用2015

    • Author(s)
      田代健太郎
    • Organizer
      日本セラミックス協会 第28回秋季シンポジウム
    • Place of Presentation
      富山大学
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] アミロイド線維の形成を抑制する抑制剤、アミロイド線維を分解する分解 剤、神経変性疾患の予防、治療および/または進展抑制のための医薬、ならびに、抑制剤 および分解剤の製造方法2015

    • Inventor(s)
      田代 健太郎、スクル クマル プラディップ
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-023490
    • Filing Date
      2015-02-09
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi