Design of beta-sheet inhibitors based on peptide metal complex arrays
| Project/Area Number |
26620139
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
TASHIRO KENTARO 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (40332598)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 多核金属錯体 / ペプチド / 自己集合 / アミロイド / アニオン依存性 / アミロイド阻害 / ペプチド金属錯体 / ホフマイスター系列 / アミロイド阻害剤 |
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| Outline of Final Research Achievements |
Design of water-soluble peptide metal complex arrays and studies on their self-assembling behaviors revealed their unique dependency on the co-existent anions, which is clearly different from the general tendency of peptides and proteins, known as “Hofmeister series” A water-soluble peptide metal complex array was found to inhibit the amyloid fibril formation of an amyloidogenic peptide and digest its preformed amylid fibers.
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Report
(3 results)
Research Products
(10 results)
