Design of beta-sheet inhibitors based on peptide metal complex arrays

• Project/Area Number: 26620139
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: National Institute for Materials Science
• Principal Investigator: TASHIRO KENTARO 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (40332598)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 多核金属錯体 / ペプチド / 自己集合 / アミロイド / アニオン依存性 / アミロイド阻害 / ペプチド金属錯体 / ホフマイスター系列 / アミロイド阻害剤

Outline of Final Research Achievements

Design of water-soluble peptide metal complex arrays and studies on their self-assembling behaviors revealed their unique dependency on the co-existent anions, which is clearly different from the general tendency of peptides and proteins, known as “Hofmeister series” A water-soluble peptide metal complex array was found to inhibit the amyloid fibril formation of an amyloidogenic peptide and digest its preformed amylid fibers.

Research Products

• [Int'l Joint Research] Jilin University(中国)
• [Journal Article] A water-soluble metal–organic complex array as a multinuclear heterometallic peptide amphiphile that shows unconventional anion dependency in its self-assembly (2016)
  • Author(s): Pradip K. Sukul, Purnandhu Bose, Toshiaki Takei, Omar M. Yaghi, Ying He, Myongsoo Lee, Kentaro Tashiro*
  • Journal Title: Chemical Communications Volume: 52 Issue: 8 Pages: 1579-1581
  • DOI: 10.1039/c5cc08973e
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Anti-Amyloid Activity of Peptide Metal Complex Arrays (2016)
  • Author(s): 田代健太郎
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸国際会議場･展示場
  • Year and Date: 2016-05-26
• [Presentation] Anti-Amyloid Activity of Peptide Metal Complex Arrays (2016)
  • Author(s): 田代健太郎
  • Organizer: 第96回春季年会
  • Place of Presentation: 同志社大学
  • Year and Date: 2016-03-27
• [Presentation] Solid-Phase Synthesis of Multi-metallated Peptide Arrays and Their Applications for Biomedical Issues (2016)
  • Author(s): 田代健太郎
  • Organizer: Vth National Symposium on Advances in Chemical Sciences
  • Place of Presentation: Guru Nanak Dev Univ., Amritsar, India
  • Year and Date: 2016-02-02
  • Int'l Joint Research / Invited
• [Presentation] Solid-Phase Synthesis of Multi-metallated Peptide Arrays and Their Applications for Biomedical Issues (2015)
  • Author(s): 田代健太郎
  • Organizer: Pacifichem 2015
  • Place of Presentation: Hawaii,Honolulu
  • Year and Date: 2015-12-19
  • Int'l Joint Research
• [Presentation] ペプチド固相合成法を利用した金属錯体ネットワークの構築と応用 (2015)
  • Author(s): 田代健太郎
  • Organizer: JAIセミナー大阪
  • Place of Presentation: ブリーゼプラザ 大阪西梅田
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] ペプチド固相合成法を利用した金属錯体ネットワークの構築と応用 (2015)
  • Author(s): 田代健太郎
  • Organizer: JAIセミナー東京
  • Place of Presentation: 朝日生命ビル 大手町サンスカイルーム
  • Year and Date: 2015-11-20
  • Invited
• [Presentation] ペプチド金属錯体アレイの固相合成と生物医学的応用 (2015)
  • Author(s): 田代健太郎
  • Organizer: 日本セラミックス協会 第28回秋季シンポジウム
  • Place of Presentation: 富山大学
  • Year and Date: 2015-09-17
  • Invited
• [Patent(Industrial Property Rights)] アミロイド線維の形成を抑制する抑制剤、アミロイド線維を分解する分解 剤、神経変性疾患の予防、治療および／または進展抑制のための医薬、ならびに、抑制剤 および分解剤の製造方法 (2015)
  • Inventor(s): 田代 健太郎、スクル クマル プラディップ
  • Industrial Property Rights Holder: 物質・材料研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-023490
  • Filing Date: 2015-02-09