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Basic Reseach on External Stimulation Responsive Drug Delivery Systems Using AC Electroosmosis

Research Project

Project/Area Number 26630035
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Design engineering/Machine functional elements/Tribology
Research InstitutionTokyo Institute of Technology

Principal Investigator

Yoshida Kazuhiro  東京工業大学, 科学技術創成研究院, 教授 (00220632)

Co-Investigator(Kenkyū-buntansha) 横田 眞一  東京工業大学, 精密工学研究所, 教授 (10092579)
金 俊完  東京工業大学, 科学技術創成研究院, 准教授 (40401517)
嚴 祥仁  東京工業大学, 科学技術創成研究院, 助教 (20551576)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords先端機能デバイス / マイクロ・ナノデバイス / 交流電気浸透 / ドラッグデリバリ―システム / 医療・福祉 / MEMS / 電鋳 / マイクロポンプ / ドラッグデリバリーシステム
Outline of Final Research Achievements

As a principal component of small-sized advanced external stimulation responsive drug delivery systems, a novel ac electroosmotic micropump using a plate-cylinder electrode array was proposed and developed. First, the micropump using a pair of plate and cylinder electrodes was proposed and characterized by simulation based on finite element method. Second, the micropump using a plate-cylinder electrode array was proposed, fabricated using micro electroforming, and characterized experimentally. Third, higher output power due to miniaturization of cylinder electrodes was experimentally confirmed. Finally, higher output power due to electric field modification by adding electrodes was investigated by simulation and experiments. A part of fundamental technologies to realize small-sized advanced external stimulation responsive drug delivery systems was established.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Characterization of an AC Electroosmotic Micropump Using Plate-Cylinder Electrode Array2015

    • Author(s)
      K. Yoshida, M. Watanabe, J.-W. Kim, S. I. Eom and S. Yokota
    • Organizer
      The 19th Int. Conf. on Mechatronics Technology (ICMT2015)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 平板-円筒電極アレイを用いた交流電気浸透マイクロポンプの開発2015

    • Author(s)
      吉田,渡邊,金,嚴,横田
    • Organizer
      平成27年春季フルードパワーシステム講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of a Novel AC Electroosmosis Micropump Using Plate-Cylinder Electrode Pair2014

    • Author(s)
      K. Yoshida, M. Watanabe, J.-W. Kim, S. I. Eom and S. Yokota
    • Organizer
      18th Int. Conf. on Mechatronics Technology (ICMT2014)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2014-10-21 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 平板-円筒電極対を用いた交流電気浸透マイクロポンプの特性評価2014

    • Author(s)
      吉田和弘,渡邊真帆,金俊完,嚴祥仁,横田眞一
    • Organizer
      日本機械学会山梨講演会
    • Place of Presentation
      山梨大学
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 平板-円筒電極を用いた交流電気浸透マイクロポンプの提案2014

    • Author(s)
      吉田和弘,渡邊真帆,金俊完,嚴祥仁,横田眞一
    • Organizer
      日本機械学会2014年度年次大会
    • Place of Presentation
      東京電機大学
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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