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Improvement of needless ice freezing method based on the model of ice formation on the biological magnetite in the tissue.

Research Project

Project/Area Number 26630062
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Thermal engineering
Research InstitutionTokyo Institute of Technology

Principal Investigator

Kobayashi Atsuko  東京工業大学, 地球生命研究所, 研究員 (50557212)

Co-Investigator(Renkei-kenkyūsha) Kirschvink Joseph  東京工業大学, 地球生命研究所, 教授 (80721258)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生体内マグネタイト / 氷晶核 / 残留磁化測定 / 過冷却 / 生体内マグネタイト氷晶モデル / Biomagnetite / SQUID magnetometory / Biogenic magnetite / Temperature monitoring / Contamination
Outline of Final Research Achievements

Our theory holds that these weak magnetic fields could be inhibiting ice-crystal nucleation on the nanocrystals of biological magnetite (Fe3O4, an inverse cubic spinel) that are present in many plant and animal tissues by causing them to oscillate. Here we report that the addition of finely-dispersed magnetite to ultrapure water samples reduces the incidence of supercooling, as measured with multiple-thermocouple experiments conducted using a standardized freezing apparatus. The probability of achieving supercooling in water samples also decreases with increasing levels of ferromagnetic contamination as measured through superconducting moment magnetometry. We also report an interesting relationship between the volume change of ice and the initial degree of supercooling, that may indicate lower degassing during the crystallization of supercooled water.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2014 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] カリフォルニア工科大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A First Test of the Hypothesis of Biogenic Magnetite-Based Heterogeneous Ice-Crystal Nucleation in Cryopreservation2016

    • Author(s)
      Kobayashi Atsuko, Harry N.Golash and Kirschvink L. Joseph
    • Journal Title

      Cryobiology

      Volume: 72 Pages: 216-224

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A First Test of the Hypothesis of Biogenic Magnetite-Based Heterogeneous Ice-Crystal Nucleation in Cryopreservation2016

    • Author(s)
      Atsuko Kobayashi1, Harry N. Golash and Joseph L. Kirschvink
    • Journal Title

      Cryobiology

      Volume: 未定 Issue: 3 Pages: 216-224

    • DOI

      10.1016/j.cryobiol.2016.04.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] On the mechanisms for the action of electric and magnetic fields in cryopreservation.2014

    • Author(s)
      Atsuko Kobayashi
    • Organizer
      World Forum on biology CRYO2014
    • Place of Presentation
      Savanna, GA USA
    • Year and Date
      2014-06-01 – 2014-06-04
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] Magnetite-Based Heterogeneous Ice-Crystal Nucleation2016

    • Inventor(s)
      A. Kobayashi and J. L.Kirschvink
    • Industrial Property Rights Holder
      A. Kobayashi and J. L.Kirschvink
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Overseas

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Published: 2014-04-04   Modified: 2022-02-21  

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