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Bio-computing that extracts coherence from chaos

Research Project

Project/Area Number 26630089
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionThe University of Tokyo

Principal Investigator

Takahashi Hirokazu  東京大学, 先端科学技術研究センター, 講師 (90361518)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳 / 神経細胞 / リカレントネットワーク / 培養 / ロボット / 微小電極アレイ / 培養神経回路 / 光刺激 / フィードバック
Outline of Final Research Achievements

In the dissociate culture, neurons seeded onto a petri dish form a network in a self-organizing manner, which generates chaotic activity patterns spontaneously. In this study, we demonstrated that a coherent output could be extracted from the chaotic activity patterns with appropriate feedback stimulation based on the network activity. A moving robot controlled with such a coherent output exhibited a goal-directed behavior, such as a maze-solving task. Our experiments suggest that biological intelligence emerges from a mechanism that extracts coherent patterns from chaotic patterns.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (28 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (22 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] チューリッヒ工科大学(スイス)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] State-Dependent Propagation of Neuronal Sub-Population in Spontaneous Synchronized Bursts2016

    • Author(s)
      Yuichiro Yada, Ryohei Kanzaki, Hirokazu Takahashi
    • Journal Title

      Frontiers in Systems Neruoscience

      Volume: 10 Pages: 1-13

    • DOI

      10.3389/fnsys.2016.00028

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reconstruction of Bursting Activity in Cultured Neuronal Network from State-space Model and Leader Spatial Activity Pattern2015

    • Author(s)
      矢田祐一郎,神崎亮平,高橋宏知
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 135 Issue: 8 Pages: 971-978

    • DOI

      10.1541/ieejeiss.135.971

    • NAID

      130005090619

    • ISSN
      0385-4221, 1348-8155
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of diverse synchrony pattern in dissociated cortical culture using Bayesian non-negative matrix factorization2015

    • Author(s)
      Yuichro Yada, Takeshi Mita, Ryohei Kanzaki, Douglas Bakkum, Hirokazu Takahashi
    • Journal Title

      Proceedings of the 7th International IEEE EMBS Neural Engineering Conference

      Volume: - Pages: 344-347

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] リザバー計算に基づく培養神経回路の状態制御2016

    • Author(s)
      安江秀太,安田秀策,矢田祐一郎,神崎亮平,高橋宏知
    • Organizer
      電気学会 医用・生体工学研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経細胞の分散培養系によるリザバー計算2016

    • Author(s)
      安田秀策,矢田祐一郎,三田毅,神崎亮平,高橋宏知
    • Organizer
      電気学会 医用・生体工学研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Estimating variety of co-active neuronal group in living neuronal network with model selection approach2015

    • Author(s)
      Yuichiro Yada, Ryohei Kanzaki, Hirokazu Takahashi
    • Organizer
      INCF Japan Node International Workshop: Advances in Neuroinformatics 2015
    • Place of Presentation
      東京
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FORCE learning implemented with a living neuronal network2015

    • Author(s)
      Shusaku Yasuda, Yuichiro Yada, Takeshi Mita, Ryohei Kanzaki, Hirokazu Takahashi
    • Organizer
      INCF Japan Node International Workshop: Advances in Neuroinformatics 2015
    • Place of Presentation
      東京
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Coordinated activation of neuronal patterns in synchrony of dissociated cortical neurons2015

    • Author(s)
      Yuichiro Yada, Ryohei Kanzaki, Hirokazu Takahashi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 培養神経回路同期パターンの独立性と予測可能性2015

    • Author(s)
      矢田祐一郎,神崎亮平,高橋宏知
    • Organizer
      ライフエンジニアリング部門シンポジウム2015
    • Place of Presentation
      福岡
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 機械屋による脳科学 知性の源泉を探る2015

    • Author(s)
      高橋宏知
    • Organizer
      DO-IT Japan project 2015
    • Place of Presentation
      東京
    • Year and Date
      2015-08-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Functional sub-network of leader neurons in self-organized dissociated cortical network2015

    • Author(s)
      Yuichiro Yada, Akihiro Sanada, Ryohei Kanzaki and Hirokazu Takahashi
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸,兵庫
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Evolved intelligence from the Darwinian principle2015

    • Author(s)
      Hirokazu Takahashi
    • Organizer
      Tokyo lectures of language evolution
    • Place of Presentation
      東京
    • Year and Date
      2015-04-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高密度CMOSアレイ上の培養神経回路の神経雪崩現象の発達過程2015

    • Author(s)
      眞田章広,矢田祐一郎,三田毅,矢野隆一,神﨑亮平,高橋宏知
    • Organizer
      電気学会 医用・生体工学研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 培養神経細胞によるFORCE学習を用いたロボット制御2015

    • Author(s)
      安田秀策,矢田祐一郎,三田毅,神﨑亮平,高橋 宏知
    • Organizer
      電気学会 医用・生体工学研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Age-dependent diversity of spontaneous synchrony in dissociated cortical network2015

    • Author(s)
      Yuichiro Yada, Takeshi Mita, Ryohei Kanzaki, Hirokazu Takahashi
    • Organizer
      脳と心のメカニズム 第15回冬のワークショップ
    • Place of Presentation
      北海道,ルスツ
    • Year and Date
      2015-01-07
    • Related Report
      2014 Research-status Report
  • [Presentation] マルチスケールな神経活動パターンに基づく神経ダーウィニズム仮説の検証2014

    • Author(s)
      高橋宏知
    • Organizer
      日本生体医工学会 専門別研究会 第11回マルチモーダル脳情報研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Reproducible spatial activity pattern in cortical network burst: characterization with non-negative matrix factorization2014

    • Author(s)
      Yuichiro Yada, Akihiro Sanada, Ryohei Kanzaki, Hirokazu Takahashi
    • Organizer
      第37回日本神経科学大会 (Neuroscience 2014)
    • Place of Presentation
      神奈川県,横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Network plasticity induced by tatanic stimulation on a single axon in dissociated neuronal culture2014

    • Author(s)
      T. Mita, D. J. Bakkum, U. Frey, A. Hierlemann, R. Kanzaki, H. Takahashi
    • Organizer
      第37回日本神経科学大会 (Neuroscience 2014)
    • Place of Presentation
      神奈川県,横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 高密度CMOSアレイ上の培養神経回路の成熟と神経雪崩現象2014

    • Author(s)
      眞田章広,矢田祐一郎,三田毅,神﨑亮平,高橋宏知
    • Organizer
      平成26年電気学会 電子・情報・システム部門大会
    • Place of Presentation
      島根
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経細胞の分散培養系におけるシナプス活動依存的な細胞移動2014

    • Author(s)
      矢野隆一,三田毅,矢田祐一郎,Douglas Bakkum,神﨑亮平,高橋宏知
    • Organizer
      平成26年電気学会 電子・情報・システム部門大会
    • Place of Presentation
      島根
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] ケージド化合物を用いた光刺激による神経細胞分散培養系の活動制御2014

    • Author(s)
      安田秀策,矢田祐一郎,三田毅,神﨑亮平,高橋宏知
    • Organizer
      平成26年電気学会 電子・情報・システム部門大会
    • Place of Presentation
      島根
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 状態空間モデルと先導空間活動パターンによる培養神経回路バースト活動の再構成2014

    • Author(s)
      矢田祐一郎,神﨑亮平,高橋宏知
    • Organizer
      平成26年電気学会 電子・情報・システム部門大会
    • Place of Presentation
      島根
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional Connectivity Estimate from Spontaneous and Stimulus Evoked Activities in Dissociated Cultured Neurons on a High-Density CMOS Microelectrode Array2014

    • Author(s)
      Takeshi Mita, Douglas J. Bakkum, Urs Frey, Andreas Hierlemann, Ryohei Kanzaki, Hirokazu Takahashi
    • Organizer
      the 9th International Meeting on Substrate-Integrated Microelectrode Arrays
    • Place of Presentation
      Reutlingen (Germany)
    • Year and Date
      2014-07-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Neuronal Migration and Activity in Mature Primary Cultures on a High-Density CMOS Array.2014

    • Author(s)
      Hirokazu Takahashi, Takeshi Mita, Satoru Okawa, Ryohei Kanzaki, Urs Frey, Andreas Hierlemann, Douglas Bakkum
    • Organizer
      the 9th International Meeting on Substrate-Integrated Microelectrode Arrays
    • Place of Presentation
      Reutlingen (Germany)
    • Year and Date
      2014-07-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 培養神経細胞における神経雪崩現象の解析2014

    • Author(s)
      眞田章広,三田毅,矢田祐一郎,神崎亮平,高橋宏知
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      宮城県,仙台
    • Year and Date
      2014-06-24
    • Related Report
      2014 Research-status Report
  • [Book] メカ屋のための脳科学入門―脳をリバースエンジニアリングする2016

    • Author(s)
      高橋宏知
    • Total Pages
      208
    • Publisher
      日刊工業新聞社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 研究代表者の個人ホームページ

    • URL

      http://www.brain.rcast.u-tokyo.ac.jp/~takahashi/

    • Related Report
      2015 Annual Research Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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