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Development of a bio-actuator by cell culture using collagen nanofibers

Research Project

Project/Area Number 26630093
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionShinshu University

Principal Investigator

HASHIMOTO Minoru  信州大学, 学術研究院繊維学系, 教授 (60156297)

Co-Investigator(Kenkyū-buntansha) 木村 建  信州大学, 学術研究院繊維学系, 教授 (20143993)
Research Collaborator SUZUKI Aya  信州大学, 繊維学部, 研究推進支援員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsバイオアクチュエータ / 人工筋肉 / コラーゲン
Outline of Final Research Achievements

To aim at creating a cell culture bio-actuator capable of exhibiting superior characteristics such as biological muscle, we studied the establishment of the myoblasts orientation control technique and the research of the electrical stimulation condition of cultured muscle cells.
As a result, about half of myotube cells for the orientation of the sheets was able to orient parallel, by the orientation control experiment with the monolayer oriented collagen sheet. And also in the study of the electrical stimulation condition of the cultured muscle cells, we found that the amount of displacement of the contractile relaxation could controlled by an electrical stimulation condition using strong contraction and we established the basic technology to control the cell culture bio-actuator.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Presentation (4 results)

  • [Presentation] 培養筋細胞の収縮挙動による電気刺激条件の検討2017

    • Author(s)
      鈴木彩、橋本稔、木村建
    • Organizer
      ロボティクス・メカトロニクス講演会2017
    • Place of Presentation
      ビッグパレットふくしま 福島県(郡山市)
    • Year and Date
      2017-05-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] コラーゲンシートを用いた培養筋芽細胞の配向性評価2016

    • Author(s)
      鈴木彩、橋本稔、木村建
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会2016
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-06-08
    • Related Report
      2015 Research-status Report
  • [Presentation] コラーゲンファイバーおよび、その集合体を用いた筋芽細胞の配向制御2015

    • Author(s)
      谷中拓実、橋本稔、木村建
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会
    • Place of Presentation
      京都市勧業館みやこめっせ(京都府京都市)
    • Year and Date
      2015-05-17 – 2015-05-19
    • Related Report
      2014 Research-status Report
  • [Presentation] コラーゲンファイバーおよび、その集合体を用いた筋芽細胞の配向制御2015

    • Author(s)
      谷中拓実、橋本稔、木村建
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会2015
    • Place of Presentation
      京都市 勧業館みやこめっせ
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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