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Challenge of Innovative Microrobot Systems to Measure Anisotropic Viscoelastic Property of Oocyte

Research Project

Project/Area Number 26630094
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionNagoya University

Principal Investigator

ARAI Fumihito  名古屋大学, 工学(系)研究科(研究院), 教授 (90221051)

Co-Investigator(Kenkyū-buntansha) ICHIKAWA Akihiko  名城大学, 理工学部, 准教授 (20377823)
Project Period (FY) 2014-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsマイクロ・ナノデバイス / 超精密計測 / マイクロマシン / 機械力学・制御 / 細胞・組織
Outline of Final Research Achievements

We conducted the research on a novel microrobot system, which enables to evaluate an anisotropy of viscoelastic property of embryo cells. Firstly, we developed the technique for transportation, positioning and rotation of embryo cells based on a vibration-induced flow on a microfluidic chip. Secondly, we integrated a miniaturized force sensor and on-chip robot to a microfluidic chip. We confirmed that the viscoelastic property of embryo cells could be evaluated by deforming the cells by the on-chip robot. We succeeded in transportation, positioning and 3D rotation of mouse oocytes on the chip by using the vibration-induced flow. Furthermore, we succeeded in a measurement of Young’s modulus of mouse oocytes by using the on-chip robot. Therefore, we succeeded to confirm the feasibility of basic principles of the microrobot system for the evaluation of anisotropy of viscoelastic property of embryo cells.

Report

(2 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (11 results)

All 2015 2014 Other

All Presentation (10 results) Remarks (1 results)

  • [Presentation] 振動誘起流れによる卵子の搬送と機械的特徴量計測2015

    • Author(s)
      中原康,佐久間 臣耶,早川健,新井史人
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会’15
    • Place of Presentation
      京都
    • Year and Date
      2015-05-17 – 2015-05-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cell manipulation method based on vibration-induced local flow control in open chip environment2015

    • Author(s)
      Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai
    • Organizer
      2015 Int. Conf. on Micro Electro Mechanical System (MEMS2015)
    • Place of Presentation
      Estoril
    • Year and Date
      2015-01-18 – 2015-01-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Si-Glass 深堀加工を 用いたロボット統合型マイ クロ流体チップの作製2014

    • Author(s)
      中原康,佐久間 臣耶,新井史人
    • Organizer
      第15回 計測自動制御学会システムインテグレーション部門講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] On-chip Cell Manipulation by Vibration-induced Whirling Flow2014

    • Author(s)
      Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai
    • Organizer
      2014 IEEE Int. Symp. on Micro-Nano Mechatronicics and Human Sciense (MHS2014)
    • Place of Presentation
      Nagoya
    • Year and Date
      2014-11-09 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 振動誘起流れを用いた細胞のオンチップ搬送・回転制御2014

    • Author(s)
      早川健,佐久間臣耶,新井史人
    • Organizer
      化学とマイクロ・ナノシステム学会第30回研究会
    • Place of Presentation
      札幌
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Three dimensional rotation of bovine oocyte by using magnetically driven on-chip robot2014

    • Author(s)
      Lin Feng, Bilal Turan, U Ningga, Fumihito Arai
    • Organizer
      2014 IEEE/RSJ International Conference on Intelligent Robots and Systems(IROS2014)
    • Place of Presentation
      Chicago
    • Year and Date
      2014-09-15 – 2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 振動誘起流れを用いたオンチップ細胞操作2014

    • Author(s)
      早川健,佐久間臣耶,新井史人
    • Organizer
      日本ロボット学会第32回学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-04 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Rotation of single bovine oocyte by micro-robot on a chip2014

    • Author(s)
      Lin Feng, U Ningga, Fumihito Arai
    • Organizer
      2014 Proceedings of the 6th International Symposium on Microchemistry and Microsystems (ISMM2014)
    • Place of Presentation
      Singapore
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポテンシャル場を用いた卵細胞の連続フィーディングによるオンチップ機械特性計測2014

    • Author(s)
      中原康,伊藤啓太郎,佐久間臣耶,新井史人
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会’14
    • Place of Presentation
      富山
    • Year and Date
      2014-05-25 – 2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 機械特性評価機能を有する卵細胞培養チップ2014

    • Author(s)
      中原康,伊藤啓太郎,佐久間臣耶,新井史人
    • Organizer
      化学とマイクロ・ナノシステム学会第29回研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学大学院工学研究科マイクロ・ナノシステム工学専攻 新井研究室 Research Fields

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp/research/research.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2016-06-03  

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