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Cubic cardiovascular platform using a chick embryo

Research Project

Project/Area Number 26630100
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionKyushu Institute of Technology

Principal Investigator

KAWAHARA Tomohiro  九州工業大学, 若手研究者フロンティア研究アカデミー, 准教授 (20575162)

Co-Investigator(Kenkyū-buntansha) OHTSUKA Hirofumi  熊本高等専門学校, 制御情報システム工学科, 教授 (10223869)
HUANG Wenjing  九州工業大学, 若手研究者フロンティア研究アカデミー, 研究員 (00633413)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords循環器シミュレータ / ニワトリ胚 / マイクロマニピュレータ
Outline of Final Research Achievements

We propose a novel platform which consists of a cubic artificial eggshell containing a chick embryo for cardiovascular simulations. The cubic eggshell with PDMS membrane allows the total amount of oxygen to pass into the egg for the chick embryo culturing. In this project, we newly developed both a new methodology to induce blood vessels into multiple PDMS channels and a tele-operated 3-DOF micromanipulator to realize the proposed platform.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Egg-in-Cube: Design and Fabrication of a Novel Artificial Eggshell with Functionalized Surface2015

    • Author(s)
      Wenjing Huang, Fumihito Arai, and Tomohiro Kawahara
    • Journal Title

      PLOS ONE

      Volume: 10(3) Issue: 3 Pages: e0118624-e0118624

    • DOI

      10.1371/journal.pone.0118624

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Egg-in-Cube: ニワトリ胚培養のための機能性透明人工殻2015

    • Author(s)
      川原知洋,黄文敬,新井史人
    • Organizer
      第38回日本分子生物学会年会/第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Egg-in-Cubeアプローチを用いたマイクロ循環器シミュレータ2015

    • Author(s)
      川原知洋,黄文敬,新井史人
    • Organizer
      第32回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inducing Blood Vessel Formation Using Cubic Eggshell with Patterned Surface2015

    • Author(s)
      W. Huang, F. Arai, and T. Kawahara
    • Organizer
      IEEE International Symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      Nagoya (Japan)
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chick Embryo-based Microvasculature Engineering2015

    • Author(s)
      T. Kawahara
    • Organizer
      IEEE NanoMed Conference
    • Place of Presentation
      Honolulu (USA)
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Egg in Cube: 機能性人工殻を用いたバイオ医療プラットホームの開発2015

    • Author(s)
      川原知洋
    • Organizer
      日本セラミックス協会第28回秋季シンポジウム
    • Place of Presentation
      富山大学 五福キャンパス
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Chick Embryo Cultured in a Cubic Eggshell as a Promising Animal Model2014

    • Author(s)
      W. Huang, F. Arai, and T. Kawahara
    • Organizer
      IEEE International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      Nagoya
    • Year and Date
      2014-11-09 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Design and Fabrication of Cubic Eggshell Containing Chick Embryo for a Novel Biomedical Platform2014

    • Author(s)
      W. Huang, F. Arai, and T. Kawahara
    • Organizer
      5th IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics
    • Place of Presentation
      Sao Paulo
    • Year and Date
      2014-08-12 – 2014-08-15
    • Related Report
      2014 Research-status Report
  • [Book] Hyper Bio Assembler for 3D Cellular Systems (Chapter 18: Bionic Simulator Based on Organ-Explant-Chip)2015

    • Author(s)
      T. Masuda, H. Owaki, T. Kawahara, and F. Arai
    • Total Pages
      349
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Remarks] 川原研究室webページ

    • URL

      http://www.lsse.kyutech.ac.jp/~kawahara/

    • Related Report
      2014 Research-status Report
  • [Remarks] 九州工業大学若手研究者フロンティア研究アカデミー

    • URL

      http://www.kyutech.ac.jp/ttacademy/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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