Liposome Physical Sensors Oriented to Label-free Integrated Chip for Early Diagnosis of Diseases Originated from Amyloid-beta Abnormality
| Project/Area Number |
26630157
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Electron device/Electronic equipment
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
Minoru Noda 京都工芸繊維大学, 電気電子工学系, 教授 (20294168)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMANOUCHI Toshinori 岡山大学, 大学院環境生命科学研究科, 准教授 (10335383)
MATSUOKA Teruyuki 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40636544)
YAMASHITA Kaoru 京都工芸繊維大学, 電気電子工学系, 准教授 (40263230)
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| Co-Investigator(Renkei-kenkyūsha) |
UMAKOSHI Hiroshi 大阪大学, 基礎工学研究科, 教授 (20311772)
NARIMOTO Jin 京都府立医科大学, 医学(系)研究科(研究院), 講師 (30347463)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | センシングデバイス / バイオセンサ / アミロイドベータ / 簡易診断 |
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| Outline of Final Research Achievements |
We have developed a new biosensing system composed of arrayed cell structure for dielectric dispersion analysis (DDA) of interaction with phospholipid membrane of liposome in order to enable to use plural different phospholipids as sensing molecule, as similar to cell membrane, and to measure simultaneously plural different target biomolecules such as proteins with different conditions. When measuring with normal human serum, we have successfully observed phenomena relating to fibrillization and/or aggregation of Aβ(1-40) with interaction of the liposomes by the DDA, also confirmed by a different sensing of cantilever sensor. Finally, we have detected 1 microM Aβ(1-40) by the DDA method, implying that the concentration in Alzheimer disease patient (20-500 nM) could be measured by an order of improvement.
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Report
(3 results)
Research Products
(82 results)
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[Journal Article] δ scores are exportable across cultural and linguistic boundaries2015
Author(s)
Royall DR, Palmer RF, Matsuoka T, Kato Y, Taniguchi S, Ogawa M, Fujimoto H, Okamura A, Shibata K, Nakamura K, Nakaaki S, Koumi H, Mimura M, Fukui K, Narumoto J.
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Journal Title
Journal of Alzheimer's Disease.
Volume: 49
Issue: 2
Pages: 561-570
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] A fluorescent arrayed biosensor using liposome encapsulating Calcein for discrimination of different target proteins by principal component analysis2015
Author(s)
R. Imamura, Z. Zhang, T. Yoshikawa, T. Shimanouchi, N. Murata, K. Yamashita, M. Fukuzawa, M. Noda
Organizer
The 47th International Conference on Solid State Devices and Materials (SSDM2015), 390-391
Place of Presentation
Sapporo Convention Center, Sapporo, Japan
Year and Date
2015-09-27
Related Report
Int'l Joint Research
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[Presentation] Detection of amyloid-beta Proteins during fibrillization process by liposome-immobilized microcantilevers in microfluidic channel2015
Author(s)
M. Sohgawa, Z. Zhang, Y. Abe, T. Abe, K. Yamashita, M. Noda
Organizer
The 47th International Conference on Solid State Devices and Materials (SSDM2015), , Sep. 27-30 (2015), 828-829
Place of Presentation
Sapporo Convention Center, Sapporo, Japan
Year and Date
2015-09-27
Related Report
Int'l Joint Research
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[Presentation] 圧電ダイアフラム型超音波センサの撓み構造と感度2015
Author(s)
山下馨, 田中 光, 荒井 開人, 西海 太貴, 野田 実
Organizer
電気学会 フィジカルセンサ バイオ・マイクロシステム 合同研究会 PHS-15-45, BMS-15-53, 電子情報通信学会 電子デバイス研究会 pp.5-9
Place of Presentation
東京都港区，機械振興会館
Year and Date
2015-08-03
Related Report
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