Development of low field EPR/NMR co-imaging system for biological samples

• Project/Area Number: 26630184
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Measurement engineering
• Research Institution: Osaka University
• Principal Investigator: AKABA Hideo 大阪大学, 基礎工学研究科, 准教授 (00552077)
• Co-Investigator(Renkei-kenkyūsha): HIRATA Hiroshi 北海道大学, 情報科学研究科, 教授 (60250958)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 磁気共鳴イメージング / 低磁場MRI / 生体EPRイメージング / EPRI/MRI融合イメージング / 電子スピン共鳴イメージング

Outline of Final Research Achievements

The purpose of the present work was developing a compact low field magnetic resonance imaging (MRI) system running　on a same magnetic circuit used for a 750 MHz CW electron paramagnetic resonance imaging (EPRI) system. A current source to drive a high inductance gradient coil of ~ a few mH with the response time of ~ 50 us was developed. We demonstrated that nuclear magnetic resonance (NMR) signal acquisition was possible without the interference of an EPR probe by setting a NMR probe located outside the EPR probe. Low field EPR/NMR co-imaging of a test sample was succeeded using the same magnetic circuit without moving the sample.

Research Products

• [Journal Article] Development of low field MRI system running on the same magnetic circuit used for 750 MHz CW EPR imaging system (2015)
  • Author(s): H. Sato-Akaba and H. Hirata
  • Journal Title: Proc. Intl. Soc. Mag. Reson. Med. Volume: 23 Pages: 3112-3112
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Development of low field MRI system running on the same magnetic circuit used for 750 MHz CW EPR imaging system (2015)
  • Author(s): 赤羽英夫、平田拓
  • Organizer: ISMRM 23rd Annual Meeting and Exhibition 2015
  • Place of Presentation: トロント (カナダ)
  • Year and Date: 2015-05-30 – 2015-06-05
• [Presentation] Development of low field MRI system running on the same magnetic circuit used for 750 MHz CW EPR imaging system (2015)
  • Author(s): H. Sato-Akaba and H. Hirata
  • Organizer: International Society for Magnetic Resonance in Medicine (ISMRM) 23th Annual Meeting and Exhibition
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research