| Project/Area Number |
26630191
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Measurement engineering
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO MITSURU 東京慈恵会医科大学, 医学部, 准教授 (50301528)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGATANI YOSHIKI 神戸市立工業高等専門学校, 准教授 (60448769)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 超音波 / 骨 / AGEｓ / コラーゲン / 架橋 / AGEs |
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| Outline of Final Research Achievements |
The effects of AGEs crosslinks on the bone elastic properties were measured as ultrasonic wave velocity changes. In the cortical bone samples of large animals, the wave velocity decreased due to the crosslinks. The wave velocity in the GHz range was measured by a Brillouin scattering technique which enables the evaluation of the small area (8 micrometer in diameter) of the bone matrix. The velocity decreases then indicates the decreases of bone matrix elasticity. The measurement of wave velocity in the MHz range was difficult. However, the three point bending test showed that the bone strength also decreased due to the crosslinks.
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