Bottom-up design of bio-molecular circuits based on structure-robust analysis
| Project/Area Number |
26630195
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Control engineering/System engineering
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Imura Jun-ichi 東京工業大学, 情報理工学(系)研究科, 教授 (50252474)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Masaki 慶應義塾大学, 理工学部, 助教 (80725680)
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| Co-Investigator(Renkei-kenkyūsha) |
AIHARA Kazuyuki 東京大学, 生産技術研究所, 教授 (40167218)
SUZUKI Masayasu 宇都宮大学, 工学部, 助教 (10456692)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 生体分子回路 / 分岐解析 / 合成生物学 / ロバスト性解析 |
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| Outline of Final Research Achievements |
In this research project, we aim to propose a new design strategy of a large-scale bio-molecular circuit which has desired functions. To this end, the following two problems are addressed. 1) For interconnected nonlinear dynamical systems, a computational method of evaluating the robustness of the structural property was proposed. The method is applied to design problem of a bio-molecular switch that models the decision maker of cell fate. 2) We found a special class of dynamical systems that reinforce the robustness via their interconnection. The class is generalized to model a bio-molecular system that expresses the differentiation of a stem cell. It is mathematically shown that the robustness of a function derived from the differentiation is reinforced via bottom-up construction. The robustness reinforcement is illustrated in numerical experiments as well.
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Report
(3 results)
Research Products
(6 results)
