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Development of single-molecule reactors for single-molecule regulated chemistry

Research Project

Project/Area Number 26630403
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Reaction engineering/Process system
Research InstitutionOsaka Prefecture University

Principal Investigator

Xu Yan  大阪府立大学, 21世紀科学研究機構, 講師 (90593898)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsアトリットル液滴 / ナノ流体デバイス / Nano-in-Nano集積化 / 1分子制御化学 / 1分子液滴反応場
Outline of Final Research Achievements

In this study, toward the realization of single-molecule regulated chemistry which is a new concept proposed by us, a method for the formation of attoliter droplets using a nanofluidic device was developed. The high-precision fabrication of local hydrophilic/hydrophobic nanopatterns in tiny nanofluidic channels, which are the core structures proposed by us for the formation of attoliter droplets, was achieved by using a nano-in-nano integration technology developed by us. The liquid-handling experimental results revealed that the fabricated nanofluidic device containing the high-precision hydrophilic/hydrophobic nanopatterns possessed the capability to form attoliter droplets based on the principle of Laplace pressure difference at the liquid/gas interface in the nanofluidic channel.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Soft Matter-Regulated Active Nanovalves Locally Self-Assembled in Femtoliter Nanofluidic Channels2016

    • Author(s)
      Yan Xu, Misato Shinomiya, Atsushi Harada
    • Journal Title

      Advanced Materials

      Volume: 28 Issue: 11 Pages: 2209-2216

    • DOI

      10.1002/adma.201505132

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regeneration of Glass Nanofluidic Chips through a Multiple-Step Sequential Thermochemical Decomposition Process at High Temperatures2015

    • Author(s)
      Yan Xu, Qian Wu, Yuji Shimatani, Koji Yamaguchi
    • Journal Title

      Lab on a Chip

      Volume: 15 Issue: 19 Pages: 3856-3861

    • DOI

      10.1039/c5lc00604j

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Flexible and In-Situ Fabrication of Nanochannels with High Aspect Ratios and Nanopillar Arrays in Fused Silica Substrates Utilizing Focused Ion Beam2015

    • Author(s)
      Yan Xu, Nobuhiro Matsumoto
    • Journal Title

      RSC Advances

      Volume: 5 Issue: 62 Pages: 50638-50643

    • DOI

      10.1039/c5ra06306j

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Site-Specific Nanopatterning of Functional Metallic and Molecular Arbitrary Features in Nanofluidic Channels2015

    • Author(s)
      Yan Xu, Nobuhiro Matsumoto, Qian Wu, Yuji Shimatani, Hiroaki Kawata
    • Journal Title

      Lab on a Chip

      Volume: 15 Issue: 9 Pages: 1989-1993

    • DOI

      10.1039/c5lc00190k

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Site-specific working inside nanofluidic channels: General methodology, critical techniques, and nanobio applications2015

    • Author(s)
      Yan Xu
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015
    • Place of Presentation
      Sheraton Waikiki Hotel, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 局所的疎水性SAM 界面による超高精度ナノ流体制御2015

    • Author(s)
      山口晃司、許岩
    • Organizer
      化学とマイクロ・ナノシステム学会第32回研究会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Site-Specific Functionalization of Nanofluidic Channels2015

    • Author(s)
      Xu Yan
    • Organizer
      International Workshop on Extended-Nanofluidics
    • Place of Presentation
      東京大学小柴ホール(東京)
    • Year and Date
      2015-03-26 – 2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] マイクロ・ナノ化学チップ技術の最前線2015

    • Author(s)
      許 岩
    • Organizer
      第12回NanoSquareカフェ
    • Place of Presentation
      大阪府立大学 I-site なんば(大阪)
    • Year and Date
      2015-03-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Functionalization of Nanofluidic Channels and its Application to NanoBio Sciences2015

    • Author(s)
      Xu Yan
    • Organizer
      Summit of Biomedical and Health Engineering (2015) of SIAT, CAS
    • Place of Presentation
      Shenzhen(China)
    • Year and Date
      2015-01-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Construction of Functional NanoBio Interfaces in Nanochannel Spaces2014

    • Author(s)
      Yan Xu
    • Organizer
      24th MRS-J
    • Place of Presentation
      Yokohama Media and Communications Center, Naka-ku, Yokohama, Kanagawa (Japan)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] ナノ流体スマート制御へ向けたチオール化温度応答性ポリマーの分子設計と合成、評価2014

    • Author(s)
      四宮未郷、原田敦史、許 岩
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Smart Nanochannel based on a thiolated temperature-responsive polymer2014

    • Author(s)
      Misato Shinomiya, Atsushi Harada, Yan Xu
    • Organizer
      RSC Tokyo International Conference 2014
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] マイクロ・ナノ界面の創製によるマイクロ・ナノ化学バイオシステムの研究2014

    • Author(s)
      許 岩
    • Organizer
      化学とマイクロ・ナノシステム学会第29回研究会
    • Place of Presentation
      日本女子大学目白キャンパス 桜楓2号館(東京)
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ナノ流路内自己組織化温度応答性界面によるナノ流体スマート制御2014

    • Author(s)
      四宮未郷、川田博昭、原田敦志、許岩
    • Organizer
      化学とマイクロ・ナノシステム学会第29回研究会
    • Place of Presentation
      日本女子大学目白キャンパス 桜楓2号館(東京)
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Research-status Report
  • [Remarks] 大阪府立大学・許研究室HP

    • URL

      http://www.chemeng.osakafu-u.ac.jp/group8/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 許研究室HP

    • URL

      http://www.nanosq.21c.osakafu-u.ac.jp/ttsl_lab/y_xu/index.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 流路構造体および流路構造体の製造方法2014

    • Inventor(s)
      許岩
    • Industrial Property Rights Holder
      許岩
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-101461
    • Filing Date
      2014-05-15
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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