Stress experiences in immature stage change the lateral habenular nucleus

• Project/Area Number: 26640009
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: University of Toyama
• Principal Investigator: Ichijo Hiroyuki 富山大学, 大学院医学薬学研究部(医学), 教授 (40272190)
• Co-Investigator(Kenkyū-buntansha): 川口 将史 富山大学, 大学院医学薬学研究部(医学), 助教 (30513056)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 外側手綱核 / 臨界期 / 母子分離ストレス / parvalbumin / 最初期遺伝子 / perineuronal net

Outline of Final Research Achievements

Structure and function of neuronal circuits are known to be modified under influences of experiences during immature stage, which is well known in mammalian sensory system as "critical period". However, nobody had examined whether there exists a critical period in emotion. Here, we report in mice that stress experiences in immature stage modify structure and function of the lateral habenular nucleus (LHb). Under influences of the repeated maternal separation, neuronal activity of the LHb was hyper-activated, which was correlated with decrease of the parvalbumin(PV)-positive neurons. Since the PV neurons belong to the GABAergic inhibitory neurons, it is thought that modification in the inhibitory neuronal circuits is involved with the experience-dependent activity changes in the LHb.

Research Products

• [Journal Article] An evolutionary hypothesis of binary opposition in functional incompatibility about habenular asymmetry in vertebrates. (2017)
  • Author(s): Ichijo H., Nakamura T., Kawaguchi M., Takeuchi Y.
  • Journal Title: Frontiers in Neuroscience Volume: 10 Pages: 595-595
  • DOI: 10.3389/fnins.2016.00595
  • NAID: 120005941588
  • Peer Reviewed / Open Access
• [Journal Article] Nervous system disruption and swimming abnormality in early-hatched pufferfish (Takifugu niphobles) larvae caused by pyrene is independent of aryl hydrocarbon receptors. (2017)
  • Author(s): Itoyama Tatsuya, Kawara Moe, Fukui Makiko, Sugahara Yuki, Kurokawa Daisuke, Kawaguchi Masahumi, Kitamura Sin-Ichi, Nakayama Kei, Murakami Yasunori.
  • Journal Title: Marine Pollution Bulletin Volume: 印刷中 Issue: 2 Pages: 30174-1
  • DOI: 10.1016/j.marpolbul.2017.02.058
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Involvement of Slit-Robo signaling in the development of the posterior commissure and concomitant swimming behavior in Xenopus laevis (2015)
  • Author(s): Yasuhiko Tosa, Kiyohito Tsukano, Tatsuya Itoyama, Mai Fukagawa, Yukako Nii, Ryota Ishikawa, Ken-Ichi T. Suzuki, Makiko Fukui, Masahumi Kawaguchi, Yasunori Murakami
  • Journal Title: Zoological letters Volume: 1 Issue: 1 Pages: 28-28
  • DOI: 10.1186/s40851-015-0029-9
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lateralization, maturation, and anteroposterior topography in the lateral habenula revealed by ZIF268/EGR1 immunoreactivity and labeling history of neuronal activity. (2015)
  • Author(s): Ichijo H, Hamada M, Takahashi S, Kobayashi M, Nagai T, Toyama T, Kawaguchi M.
  • Journal Title: Neurosci Res Volume: 95 Pages: 27-37
  • DOI: 10.1016/j.neures.2015.01.005
  • NAID: 120005539542
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of the thalamo-DVR tract in the Chinese soft-shelled turtle Pelodiscus sinensis. (2014)
  • Author(s): Tosa, Y., Hirao, A., Matsubara, I., Kawaguchi, M., Nagashima, H., Kuratani, S., and Murakami, Y.
  • Journal Title: Dev. Growth Diff. Volume: 57 Issue: 1 Pages: 40-57
  • DOI: 10.1111/dgd.12186
  • Peer Reviewed
• [Presentation] Neural basis of premating isolation in Rhinogobius species. (2016)
  • Author(s): Kawaguchi M, Matsumoto K, Nakayama K, Yamamoto N, Shibata J, Sogabe A, Kawanishi R, Yamasaki Y, Akazome Y, Suto F, Ichijo H, Murakami Y
  • Organizer: 第39回 日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Lateralization, maturation, and anteroposterior topography in the lateral habenula revealed by ZIF268/EGR1 immunoreactivity and labeling history of neuronal activity (2015)
  • Author(s): Hiroyuki Ichijo, Masafumi Kawaguchi
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2015-07-30
• [Presentation] Neural basis of reproductive isolation in Rhinogobius species (2015)
  • Author(s): Masafumi Kawaguchi, Koji Matsumoto, Kei Nakayama, Naoyuki Yamamoto, Yasuhisa Akazome, Fumikazu Suto, Hiroyuki Ichijo, Yasunori Murakami
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2015-07-29
• [Remarks] 富山大学 医学部 解剖学・神経科学講座
  • URL: http://www.med.u-toyama.ac.jp/anat/index.html