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Development of Visualization System for Neural Stem Cell Niche

Research Project

Project/Area Number 26640013
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research Institution地方独立行政法人佐賀県医療センター好生館(ライフサイエンス研究所)

Principal Investigator

KANKI Hiroaki  地方独立行政法人佐賀県医療センター好生館(ライフサイエンス研究所), ライフサイエンス研究所, 研究員 (80321751)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経幹細胞 / ニッチ / 幹細胞 / 神経新生 / ニッシェ
Outline of Final Research Achievements

As a pilot system for precise identification of neural (or other cell types of) stem cell niches in adult mammals, I tried in this study to develop a visualization system for “neural stem cell (NSC)-surrounding cells,” utilizing fluorescent proteins. Briefly, a fluorescent peptide is to be secreted from NSCs and then immediately taken up by the surrounding cells, which are a counterpart for NSC niche-constituting cells. Through a set of evaluation processes, I confirmed that NSC-surrounding cells were indeed fluorescently-labeled, as planned. The intensity of the fluorescence, however was much lower than expected, suggesting that the system needs additional modifications.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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