Role of clonally-related neurons in hippocampal neuronal circuit
| Project/Area Number |
26640020
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HAYASHI Yasunori 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (90466037)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 神経科学 / 脳・神経 |
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| Outline of Final Research Achievements |
The cluster of neurons which differentiated from progenitor cells are called clonally-related neurons. In this study, we analyzed neuronal activity of clonally-related neurons using Ca2+ sensor protein and retrovirus vector for labeling clonally-related neurons. At 12 days after fertilization, retrovirus was injected into subventricular zone through uterine wall. Infected neurons in hippocampal CA1 region were imaged using two photon microscope at 2 month later after birth and we can see the clonally-related neurons in hippocampal CA1 region. When we analyse the neuronal activity in clonally-related neurons, it is indicated that firing rate of clonally-related neurons were lower than other neurons.
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Report
(2 results)
Research Products
(12 results)
